JW-55
JW-55
CAS: 664993-53-7
Molecular Formula: C25H26N2O5
JW-55 - Names and Identifiers
JW-55 - Physico-chemical Properties
| Molecular Formula | C25H26N2O5 |
| Molar Mass | 434.48 |
| Density | 1.235±0.06 g/cm3(Predicted) |
| Boling Point | 572.6±50.0 °C(Predicted) |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 12.41±0.70(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. |
| In vivo study | JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice. |
JW-55 - Risk and Safety
| WGK Germany | 3 |
JW-55 - Reference
| Reference Show more | 1. [IF=5.914] Jing Xie et al."Short-chain fatty acids produced by Ruminococcaceae mediates α-Linolenic acid promote intestinal stem cells proliferation."Molecular Nutrition & Food Research. 2021 Oct 28 |
JW-55 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.302 ml | 11.508 ml | 23.016 ml |
| 5 mM | 0.46 ml | 2.302 ml | 4.603 ml |
| 10 mM | 0.23 ml | 1.151 ml | 2.302 ml |
| 5 mM | 0.046 ml | 0.23 ml | 0.46 ml |
Last Update：2024-01-02 23:10:35
JW-55 - Reference Information
| biological activity | JW55 is an effective and selective classical Wnt signaling pathway inhibitor, which works by inhibiting the PARP region of TNKS1/2. |
| target | TargetValue Wnt () |
| Target | Value |
| in vitro study | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μ m in SW480 cells and 0.01 to 5 μ m in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. |
| in vivo study | JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice. |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: JW-55 Visit Supplier Webpage Request for quotationCAS: 664993-53-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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