JZL195

Name	4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
Synonyms	JZL195 JZL-195 CS-1586 JZL 195 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester 1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
CAS	1210004-12-8

Molecular Formula	C24H23N3O5
Molar Mass	433.46
Density	1.303±0.06 g/cm3(Predicted)
Boling Point	581.8±50.0 °C(Predicted)
Solubility	DMSO : 50 mg/mL (115.35 mM; Need ultrasonic)
Appearance	powder
Color	white to beige
pKa	6.13±0.10(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Use	JZL195 is an effectively selected dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) with IC50s of 2 and 4 nM, respectively.
In vitro study	JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC 50 values of 13 and 19 nM, respectively). JZL195 inhibits rat and human FAAH and MAGL enzymes with IC 50 values in the range of ≈10-100 nM based on competitive ABPP assays.
In vivo study	JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. Animal Model: Male C57BL/6J mice Dosage: 20 mg/kg Administration: Intraperitoneal injection Result: Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.

Hazard Symbols	N - Dangerous for the environment
Risk Codes	50 - Very Toxic to aquatic organisms
Safety Description	61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3

Last Update：2024-01-02 23:10:35

biological activity	JZL195 is a potent FAAH and MAGL inhibitor with IC50 of 2 nM and 4 nM, respectively.
Target	TargetValue FAAH () 2 nM MAGL () 4 nM
Target	Value
FAAH ()	2 nM
MAGL ()	4 nM
In vitro studies	JZL195 products near-complete block of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC 50 values 13 and 19 nM, review). JZL195 inhibitors rat and human FAAH and MAGL enzymes with IC 50 values in the range of ≈ 10-100 nM based on competitive ABPP asays.
in vivo studies	JZL195 (20 mg/kg; I. p.) produces an antinociceptive response in the tail immersion assay. Animal Model: Male C57BL/6J mice Dosage: 20 mg/kg: produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
Animal Model:	Male C57BL/6J mice
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection
Result:	Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.

Last Update：2024-04-09 20:49:11

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