K0-3861
K03861
CAS: 853299-07-7
Molecular Formula: C24H26F3N7O2
K0-3861 - Names and Identifiers
| Name | K03861 |
| Synonyms | KO3861 K03861 K0-3861 AUZ 454 CS-2904 K0 3861 AUZ 454 (K03861) 1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- |
| CAS | 853299-07-7 |
K0-3861 - Physico-chemical Properties
| Molecular Formula | C24H26F3N7O2 |
| Molar Mass | 501.5 |
| Solubility | DMSO: ≥ 33 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | K03861 inhibits CDK2 activity by competitively binding activated cyclins. |
K0-3861 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.994 ml | 9.97 ml | 19.94 ml |
| 5 mM | 0.399 ml | 1.994 ml | 3.988 ml |
| 10 mM | 0.199 ml | 0.997 ml | 1.994 ml |
| 5 mM | 0.04 ml | 0.199 ml | 0.399 ml |
Last Update：2024-01-02 23:10:35
K0-3861 - Reference Information
| biological activity | K03861 (AUZ 454,AUZ454) is a type II CDK2 inhibitor that acts on CDK2(WT), the Kd of CDK2(C118L),CDK2(A144C), and CDK2(C118L/A144C) are 50 nM,18.6 nM,15.4 nM, and 9.7 nM, respectively. |
| Target | Value |
| CDK2(C118L/A144C) (Cell-free assay) | 9.7 nM(Kd) |
| CDK2(A144C) (Cell-free assay) | 15.4 nM(Kd) |
| CDK2(C118L) (Cell-free assay) | 18.6 nM(Kd) |
| CDK2(WT) (Cell-free assay) | 50 nM(Kd) |
Last Update：2024-04-09 21:54:55
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CAS: 853299-07-7
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CAS: 853299-07-7
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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