K252c

Name	K252c
Synonyms	K252c K-252C Staurosporinone STAUROSPORINE AGLYCONE Staurosporinone, K-252c K-252c(Staurosporinone) 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
CAS	85753-43-1

Molecular Formula	C20H13N3O
Molar Mass	311.34
Melting Point	>200°C (dec.)
Water Solubility	Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water.
Solubility	DMSO: 10mg/mL, soluble
Appearance	solid
Color	Pale Brown to Light Brown
Storage Condition	−20°C

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
UN IDs	NA 1993 / PGIII
WGK Germany	3
HS Code	29333990

biological activity	K-252c, an analog of cruciosporine, which can be separated from Nocardiopsis sp. It is a PKC inhibitor that can penetrate cells, and the IC50 value is 2.45 µM. K-252c can induce apoptosis of human chronic myeloid leukemia cancer cells. K-252c can also inhibit β-lactamase, chymotrypsin and malate dehydrogenase.
target	IC50: 2.45 µM (PKC).

Last Update：2024-04-09 21:04:16

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CAS: 85753-43-1
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Mobile: 86+15671228036
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K252c

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