KC-404
Ibudilast
CAS: 50847-11-5
Molecular Formula: C14H18N2O
KC-404 - Names and Identifiers
| Name | Ibudilast |
| Synonyms | Ketas KC-404 Eyevinal Ibudilast IBUDILAST IBUDILAST-D7 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL] |
| CAS | 50847-11-5 |
| EINECS | 637-150-7 |
| InChI | InChI=1/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3 |
| InChIKey | ZJVFLBOZORBYFE-UHFFFAOYSA-N |
KC-404 - Physico-chemical Properties
| Molecular Formula | C14H18N2O |
| Molar Mass | 230.31 |
| Density | 1.09 |
| Melting Point | 53-54°C |
| Boling Point | 175°C/7.5mmHg(lit.) |
| Solubility | DMSO: 28mg/mL, soluble |
| Appearance | solid |
| Color | white |
| Merck | 14,4879 |
| pKa | 1.22±0.30(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00864808 |
| Physical and Chemical Properties | Colorless plate-like crystal or white crystalline powder, melting point 53.5-54 ℃ (hexane). Soluble in organic solvents, slightly soluble in water. Acute toxicity LD50 male and female mice, male and female rats (mg/kg):1880,1860,1340,1390 oral;>3000,3100,1450,1300 subcutaneous injection; 460,500,550,419 intraperitoneal injection; 160,146,43.2,42.5 intravenous injection. |
KC-404 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | UR0711200 |
| Toxicity | LD50 i.v. in mice: 260 mg/kg (Irikura, 1973) |
KC-404 - Nature
Open Data Verified Data
A colorless plate-like crystal or a white crystalline powder, crystallized from hexane, has a melting point of 53.5 to 54 °c. Soluble in organic solvents, slightly soluble in water.
Last Update：2024-01-02 23:10:35
KC-404 - Preparation Method
Open Data Verified Data
1-amino -2-methyl pyridinium halide and isobutyric anhydride, in the presence of potassium carbonate and sodium acetate reaction, namely ibudilast.
Last Update：2022-01-01 09:23:01
KC-404 - Use
Open Data Verified Data
ibudilast is a new specific Antiasthmatic agent, leukotriene receptor antagonist. For bronchial asthma, can improve the sequelae of cerebral infarction, cerebral hemorrhage sequelae and cerebral arteriosclerosis in patients with subjective symptoms.
Last Update：2022-01-01 09:23:02
KC-404 - Safety
Open Data Verified Data
mice were injected intravenously with LD50: 260mg/kg.
Last Update：2022-01-01 09:23:02
KC-404 - Reference Information
| biological activity | Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities. |
| Target | Value |
| PDE4 (Bovine aortic EC) | 0.08 μM |
| PDE2 (Bovine aortic EC) | 0.11 μM |
| PDE5 (Human platelets) | 2.2 μM |
| use | is used for bronchial asthma, which can improve the sequelae of cerebral infarction, sequelae of cerebral bleeding and conscious symptoms of patients with cerebral arteriosclerosis. |
| Production method | 1-amino-2-methylpyridine anchor halide and isobutyric anhydride, react in the presence of potassium carbonate and sodium acetate, That is to obtain Ibustine. |
Last Update：2024-04-10 22:29:15
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Product Name: Ibudilast Visit Supplier Webpage Request for quotationCAS: 50847-11-5
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Spot supply
Product Name: Ibudilast Visit Supplier Webpage Request for quotationCAS: 50847-11-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Ibudilast Visit Supplier Webpage Request for quotationCAS: 50847-11-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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