KGN人卵巢颗粒复苏细胞(附STR鉴定报告)
Kartogenin
CAS: 4727-31-5
Molecular Formula: C20H15NO3
KGN人卵巢颗粒复苏细胞(附STR鉴定报告) - Names and Identifiers
| Name | Kartogenin |
| Synonyms | KGN Kartogenin Kartogenin(KGN) 4'-Phenylphthalanilic Acid 4′-Phenyl-phthalanilic acid (8CI) 2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid 2-([1,1'-biphenyl]-4-ylcarbaMoyl)benzoic acid 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid |
| CAS | 4727-31-5 |
| InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
KGN人卵巢颗粒复苏细胞(附STR鉴定报告) - Physico-chemical Properties
| Molecular Formula | C20H15NO3 |
| Molar Mass | 317.338 |
| Density | 1.289±0.06 g/cm3(Predicted) |
| Melting Point | 272 °C |
| Boling Point | 464.4±38.0 °C(Predicted) |
| Solubility | DMSO: ≥ 42 mg/mL |
| Appearance | powder |
| Color | White |
| pKa | 3.45±0.36(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Physical and Chemical Properties | Bioactive Kartogenin (KGN) is a smad4/smad5 pathway activator, which promotes the selective differentiation of multifunctional mesenchymal stem cells into chondrocytes. |
KGN人卵巢颗粒复苏细胞(附STR鉴定报告) - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
KGN人卵巢颗粒复苏细胞(附STR鉴定报告) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.756 ml | 31.512 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.302 ml |
| 10 mM | 0.315 ml | 1.576 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
KGN人卵巢颗粒复苏细胞(附STR鉴定报告) - Uses and synthesis methods
Target
Target Value
Smad4
Smad5
in vitro studies
Kartogenin induced hMSCs to differentiate into chondrocytes and protected articular chondrocytes by enhancing CBFβ nuclear localization. Kartogenin promotes type I collagen synthesis of dermal fibroblasts by activating the smad4/smad5 pathway without significant cytotoxicity to the activity, morphology and survival of fibroblasts.
In vivo studies
In mouse models of OA caused by collagenase VII (10 μM)-and surgical (100 μM)-Kartogenin promote cartilage repair. Kartogenin (100 nM) also stimulates collagen synthesis in mouse dermis. In addition, Kartogenin stimulated bone growth and synovial joint development in mouse limbs.
Last Update：2024-04-09 21:01:54
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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View History
KGN人卵巢颗粒复苏细胞(附STR鉴定报告)
(2S,4R)-4-羟基-1-((S)-3-甲基-2-(1-氧代异吲哚啉-2-基)丁酰基)-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺
2-[[(3-氯-2-甲基苯基)氨基]甲基]异吲哚啉-1,3-二酮
4-溴-3-乙氧基-5-甲基异噁唑
3-AMINOPHTHALIC ACID HYDROCHLORIDE 1-HYDRATE
2,2-二(4-羟基苯基)金刚烷二缩水甘油醚
Etrasimod Impurity 11-d9 (rac-Etrasimod-d9)
SODIUM DIBUTYLDITHIOCARBAMATE
更昔洛韦API和中间体
1.4-DICHLORO-2-BUTENE CIS & TRANS SOLUTION 100UG/ML IN METHANOL 5ML
(2S,4R)-4-羟基-1-((S)-3-甲基-2-(1-氧代异吲哚啉-2-基)丁酰基)-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺
2-[[(3-氯-2-甲基苯基)氨基]甲基]异吲哚啉-1,3-二酮
4-溴-3-乙氧基-5-甲基异噁唑
3-AMINOPHTHALIC ACID HYDROCHLORIDE 1-HYDRATE
2,2-二(4-羟基苯基)金刚烷二缩水甘油醚
Etrasimod Impurity 11-d9 (rac-Etrasimod-d9)
SODIUM DIBUTYLDITHIOCARBAMATE
更昔洛韦API和中间体
1.4-DICHLORO-2-BUTENE CIS & TRANS SOLUTION 100UG/ML IN METHANOL 5ML