KNK423
KNK437
CAS: 218924-25-5
Molecular Formula: C13H11NO4
KNK423 - Names and Identifiers
KNK423 - Physico-chemical Properties
| Molecular Formula | C13H11NO4 |
| Molar Mass | 245.23 |
| Solubility | DMSO: ≥ 34 mg/mL |
| Appearance | White to light yellow powder |
| Color | white to beige |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | In COLO 320DM (human colon cancer) cells, KNK437 dose-dependently inhibited the acquisition of Thermotolerance and the activity of individual HSPs, including Hsp105, HSP70 and hsp40. KNK437 and quercetin dose-dependently inhibited Thermotolerance in PC-3 cells. KNK437 reduced heat-induced accumulation of HSP70 mRNA and protein in PC-3 and LNCaP cells. |
| In vivo study | KNK437(200 mg/kg, I. P.) showed no anti-tumor effect and did not increase the temperature sensitivity of non-resistant tumors. The same dose of KNK437 synergistically increased the anti-tumor efficacy of the graded heat treatment. |
KNK423 - Risk and Safety
| WGK Germany | 3 |
KNK423 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.078 ml | 20.389 ml | 40.778 ml |
| 5 mM | 0.816 ml | 4.078 ml | 8.156 ml |
| 10 mM | 0.408 ml | 2.039 ml | 4.078 ml |
| 5 mM | 0.082 ml | 0.408 ml | 0.816 ml |
Last Update：2024-01-02 23:10:35
KNK423 - Reference Information
| Introduction | KNK437 (218924-25-5) Inhibits Constitutive and inducible HSP70 expression in non-stressed and heat-stressed cancer cells. Blocks geldanamycin-induced HSP70 induction and inhibition of TGF signaling. Inhibition of leukocyte integrin α-7-mediated T cell adhesion to Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) suggests that HSP70 is critical for 7 integrin signaling. Inhibits morphine analgesia tolerance in a rodent model (100 mg/Kg). |
| biological activity | KNK437 is a pan-HSP inhibitor that inhibits inducible HSPs, including HSP105,HSP72, and synthesis of hsp40. |
| Target | TargetValue HSP105 () HSP72 () HSP40 () |
| Target | Value |
| in vitro study | in COLO 320DM (human colon cancer) cells, KNK437 dose-dependently inhibited the acquisition of Thermotolerance and the activity of individual HSPs, including Hsp105, HSP70 and hsp40. KNK437 and quercetin dose-dependently inhibited Thermotolerance in PC-3 cells. KNK437 reduced heat-induced accumulation of HSP70 mRNA and protein in PC-3 and LNCaP cells. |
| in vivo studies | KNK437(200 mg/kg, I. P.), and does not increase the temperature sensitivity of non resistant tumors. The same dose of KNK437 synergistically increased the anti-tumor efficacy of the graded heat treatment. |
Last Update：2024-04-09 20:44:15
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Spot supply
Product Name: KNK437 Visit Supplier Webpage Request for quotationCAS: 218924-25-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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