L-732,138

Name	N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be
Synonyms	L732138 L-732,138 AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER 3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
CAS	148451-96-1
InChI	InChI=1/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1

Molecular Formula	C22H18F6N2O3
Molar Mass	472.38
Density	1.396±0.06 g/cm3(Predicted)
Melting Point	147-148°C(lit.)
Boling Point	554.1±50.0 °C(Predicted)
Flash Point	288.9°C
Vapor Presure	2.56E-12mmHg at 25°C
Appearance	powder
pKa	14.63±0.46(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Refractive Index	1.541

WGK Germany

biological activity	L-732138 (L-732,138) is an effective and selective competitive antagonist of neurokinin-1 (NK-1) receptor/substance P (SP) receptor. L-732138 inhibited the binding of 125I-SP to stably expressed human NK-1 receptors in CHO cells with an IC50 value of 2.3 nM.
Target	Value
NK-1 receptor (in CHO cells)	2.3 nM
Cell Line:	COLO 858, MEL HO and COLO 679 cells
Concentration:	0 µM, 20 µM, 40 µM, 60 µM, 80 µM, 100 µM
Incubation Time:	First doubling time
Result:	Resulted in a concentration-dependent cytotoxicity. Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues.
Animal Model:	Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)
Dosage:	10 -4 mol/kg , 10 -3 mol/kg and 10 -2 mol/kg
Administration:	Intravenous injection; for 15 minutes