L-771688

Name	L-771688
Synonyms	L-771688 200050-59-5 5-Pyrimidinecarboxylic acid, 6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-1-[[[3-[4-(2-pyridinyl)-1-piperidinyl]propyl]amino]carbonyl]-, methyl ester, (6S)-
CAS	200050-59-5

Molecular Formula	C28H33F2N5O5
Molar Mass	557.59
Density	1.274±0.06 g/cm3(Predicted)
Solubility	DMSO
pKa	10.90±0.70(Predicted)
Storage Condition	-20℃
In vitro study	Specific [ 3 H]L-771688 binding to cloned human α1A-Adrenoceptors is inhibited with high potency by subtype selective compounds, GG818 (K i =0.026±0.002 nM) and L-771688 (K i =0.052±0.008 nM) and subtype non-selective α1-adrenoceptor antagonists, prazosin (K i =0.088±0.0.032 nM) and terazosin (K i =1.8±0.65 nM). The relative amount of [ 3 H]L-771688 (0.5 nM) binding in various rat tissue membranes is highest in submaxillary gland (9.5 pmol/g tissue), followed by brain (5.8 pmol/g tissue), vas deferens (4.3 pmol/g tissue), kidney (3.4 pmol/g tissue), heart (1.5 pmol/g tissue), urethra (1.1 pmol/g tissue) and prostate (0.88 pmol/g tissue). In contrast, low specific [ 3 H]L-771688 binding is observed in rat urinary bladder (0.55 pmol/g tissue), liver (0.44 pmol/g tissue), aorta (0.11 pmol/g tissue) and spleen (0.11 pmol/g tissue).

Product Name: L-771688 Visit Supplier Webpage Request for quotation
CAS: 200050-59-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: L-771688 Visit Supplier Webpage Request for quotation
CAS: 200050-59-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

L-771688

L-771688 Request for Quotation