L-Carnitine-L-tartrate
L-Carnitine-L-Tartrate
CAS: 36687-82-8
Molecular Formula: C11H20NO9-
L-Carnitine-L-tartrate - Names and Identifiers
| Name | L-Carnitine-L-Tartrate |
| Synonyms | L-CARNITINE TARTRATE L-CARNITINE L-TARTRATE L-CARNITINE-1-TARTRATE N,N-Dimethyl benzamine L-Carnitine-L-Tartrate L-Carnipure(R) tartrate L-CARNITINETARTRATE,POWDER L-(-)-CARNITINE-L-(-)-TARTRATE L-Carnitine L-Tartrate (factory standard) (R)-BIS[(3-CARBOXY-2-HYDROXYPROPYL) TRIMETHYL AMMONIUM] L-TARTRATE 1-Propanaminium, 3-carboxy-2-(3-carboxy-2,3-dihydroxy-1-oxopropoxy)-N,N,N-trimethyl-, inner salt, ion(1-), (2S)- |
| CAS | 36687-82-8 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C11H19NO8/c1-12(2,3)5-6(4-7(13)14)20-11(19)9(16)8(15)10(17)18/h6,8-9,15-16H,4-5H2,1-3H3,(H-,13,14,17,18)/p-1/t6-,8?,9?/m0/s1 |
| InChIKey | KCSRITPMKZWOGA-FYZOBXCZSA-N |
L-Carnitine-L-tartrate - Physico-chemical Properties
| Molecular Formula | C11H20NO9- |
| Molar Mass | 310.28 |
| Density | 1.216 at 20℃ |
| Melting Point | 217-219℃ |
| Boling Point | 196.6℃ at 101.3kPa |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 20-134hPa at 35-50℃ |
| Appearance | White crystal |
| Color | White to Off-White |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Easily absorbing moisture |
| Physical and Chemical Properties | White (slightly yellowish) powder, tasteless and odorless. Soluble in dilute acid, soluble in water, insoluble in ethanol, ether and chloroform and other organic solvents. It is resistant to light and heat, stable in air and hygroscopic. The oral LD50 of mice is more than 21.5 g/kg. |
| Use | Used in medicine and health products, food additives, etc |
L-Carnitine-L-tartrate - Reference Information
| LogP | -2.9 at 50℃ and pH5.54 |
| surface tension | 55mN/m at 1g/L and 20 ℃ |
| Introduction | L-carnitine tartrate, also known as L-carnitine or propionyl-L-carnitine, is considered to be the biologically active form of carnitine in the human body. It is stored in almost all parts of the human body, but mainly in muscle cells, including those of the heart. L-carnitine tartrate is the stable situation of L-carnitine. The active ingredient is still L-carnitine, but the content is only 32%. The other 68% is tartaric acid. Its function and effect are exactly the same as L-carnitine. It is generally used for capsule and tablet production. my country's food additive hygiene standards GB2760-1996 stipulate that L-carnitine tartrate is a food nutrition fortifier, which can be used in chewable tablets, drinks, capsules, milk powder and milk beverages. |
| physiological effects | l-carnitine tartrate is mainly concentrated in muscle. The significance is that the main function of the compound is to provide an additional source of ATP for this form of highly metabolic tissue. Due to its role in mobilizing fat into muscle tissue, the presence of L-carnitine actually helps improve muscle endurance because of the increased energy supply. At the same time, it also helps to improve endurance by maintaining the storage of muscle glycogen and preventing the accumulation of lactic acid. L-carnitine tartaric acid is considered a good weight loss supplement due to its increased ability to mobilize fat. |
| Discovery history | The study of L-carnitine began in the early 20th century. In 1905, Russian Gulewitsch and Krimberg discovered L-carnitine from meat extract. Since then, scientists from various countries have conducted in-depth research. Early research found that L-carnitine is a kind of vitamin nutrient and named it Vitamin Bt. In fact, the chemical structure of alkali is similar to choline, similar to amino acids; in addition, because some animals can synthesize themselves to meet the needs of carnitine, they think carnitine is not a vitamin, but it is still called vitamin BT. The Food and Nutrition Committee of the American Academy of Sciences extensively reviewed research on L-carnitine and concluded in 1989 that "L-carnitine is not a necessary nutrient" and does not require "recommended intake". At the International Conference on Nutrition held in Chicago in 1985, L-carnitine was designated as a "multifunctional nutrition". |
| Source | Red meat is the main source of L-carnitine and has no toxic side effects on the human body. Different types of daily diets already contain 5-100 mg of L-carnitine, but the average person can only consume 50 mg from the diet every day, and vegetarians consume less. The main physiological function of L-carnitine is to promote the conversion of fat into energy. Taking L-carnitine can reduce body fat and weight without reducing water and muscle. In 2003, it was recognized as the safest without side effects by the International Obesity Health Organization. Weight loss nutritional supplement. |
| traits | L-carnitine tartrate is a white crystalline powder. L-carnitine tartrate is a stable form of L-carnitine. It is not easy to absorb moisture and remains stable under humid conditions. There is a pleasant acidic smell. Easily soluble in water, but not easily soluble in organic solvents. |
| use | l carnitine tartrate can be used as a nutritional enhancer, medicine, especially suitable for solid preparations. Used as a feed nutrition fortifier. used in medicine and health products, food additives, etc. application: L-carnitine tartrate is an ideal form of L-carnitine, suitable for solid preparations, especially for tablets and capsules. |
| application | l-carnitine tartrate is an ideal form of l-carnitine application, suitable for solid preparations, especially for tablets and capsules. L-carnitine tartrate is widely used in health products, food and cosmetics industries. |
| production method | add 10g(0.057mol)L-ascorbic acid and 250mL acetone to a 500mL flask, then add 5.2% stannous chloride (SnCL2 · 2H2O) catalyst in the amount of L-ascorbic acid (AA), 2 zeolites, 1 Soxhlet extractor on the flask, and 20g of anhydrous sodium sulfate (wrapped with dry filter paper), reflux at 80 ℃ for 1.5h, and stop after AA reaction. Filtration, atmospheric distillation of the filtrate to recover acetone, after most of the acetone is evaporated, a small amount of n-hexane is added, cooling and suction filtration, the product is washed with a small amount of 4:7 (volume ratio) acetone n-hexane, and the white product IAA11.6 g is dried, the yield is 94.3%, and the melting point is 217-219 ℃. Using water as solvent, adding 2.2mol/L pyridine and 10mol/L potassium hydroxide (PH = 12-12.5), adding slightly excess phosphorus oxychloride in IAA at 0-10 ℃, and neutralizing with magnesium oxide after refining with cation exchange resin to obtain the product with a yield of more than 70%. |
Last Update：2024-04-09 20:52:54
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