LDC-000067

Name	LDC000067
Synonyms	LDC067 LDC 067 LDC-067 CS-1535 LDC000067 LDC-000067 LDC 000067 (3-(6-(2-Methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanesulfonamide 3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide
CAS	1073485-20-7

Molecular Formula	C18H18N4O3S
Molar Mass	370.43
Density	1.360±0.06 g/cm3(Predicted)
Boling Point	604.1±65.0 °C(Predicted)
Solubility	DMSO: ≥ 47 mg/mL
pKa	10.27±0.60(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
In vitro study	LDC000067 reduces mESCs by Ser2-P, induces p53 activation, and leads to apoptosis. In addition, LDC067 also dose-dependently inhibited the de novo RNA synthesis of P-TEFb-dependent cellular genes.

Last Update：2024-01-02 23:10:35

biological activity	LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, which is 55/125/210/227/ >227 times higher than the selectivity of CDK2/1/4/6/7 respectively.
target	TargetValue CDK9 (cell-free assay) 44 nM CDK2 (cell-free assay) 2.441 μM
Target	Value
CDK9 (Cell-free assay)	44 nM
CDK2 (Cell-free assay)	2.441 μM
in vitro study	LDC000067 reduce Ser2-P in mESCs, induce p53 activation, and lead to apoptosis. In addition, LDC067 also dose-dependently inhibits RNA de novo synthesis of P-TEFb-dependent cellular genes.

Last Update：2024-04-09 21:11:58

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CAS: 1073485-20-7
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Product Name: LDC000067 Visit Supplier Webpage Request for quotation
CAS: 1073485-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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LDC-000067

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