LDN-214117
LDN-214117
CAS: 1627503-67-6
Molecular Formula: C25H29N3O3
LDN-214117 - Names and Identifiers
LDN-214117 - Physico-chemical Properties
| Molecular Formula | C25H29N3O3 |
| Molar Mass | 419.52 |
| Density | 1.134±0.06 g/cm3(Predicted) |
| Boling Point | 567.9±50.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 8.86±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | The kinase most highly inhibited by LDN-214117 is ALK2 (IC50, 24 nM), followed by TNIK, RIPK2, and ABL1. LDN-214117 demonstrates selective inhibition of ALK2 and ALK1 in preference to ALK3 kinase activity. LDN-214117 exhibits relatively selective inhibition of BMP6 versus BMP2 or BMP4. In a cell-based assay, LDN-214117 exhibits a selective inhibition on BMP6 with IC50 of approximately 100 nM, and 164-fold selectivity for BMP6 versus TGF-β1. |
LDN-214117 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
LDN-214117 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.384 ml | 11.918 ml | 23.837 ml |
| 5 mM | 0.477 ml | 2.384 ml | 4.767 ml |
| 10 mM | 0.238 ml | 1.192 ml | 2.384 ml |
| 5 mM | 0.048 ml | 0.238 ml | 0.477 ml |
Last Update：2024-01-02 23:10:35
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Product Name: LDN-214117 Visit Supplier Webpage Request for quotation
CAS: 1627503-67-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1627503-67-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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