LOX0292
LOXO-292
CAS: 2222755-14-6
Molecular Formula: C29H31N9O3
LOX0292 - Names and Identifiers
LOX0292 - Physico-chemical Properties
| Molecular Formula | C29H31N9O3 |
| Molar Mass | 553.61 |
| Density | 1.49±0.1 g/cm3(Predicted) |
| pKa | 8.23±0.40(Predicted) |
| Use | Uses selpatinib (LOXO-292) is a potent, oral, highly selective rearranged during transfection (RET) kinase inhibitor for the treatment of RET abnormal cancer patients. The RET gene, a proto-oncogene that rearranges during transfection, encodes a cell membrane receptor tyrosine kinase whose abnormality is a rare driver of many types of tumors. |
LOX0292 - Synthesis of serpatinib
Application (Patent) No.:
202110688238
Applicant (patentee):
Jiangsu Huiju Pharmaceutical Co., Ltd
Inventor:
Wang Junqiang ,< a href = "https://xueshu.baidu.com/s?wd=author: (Qiu Xiaolong) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Qiu Xiaolong ,< a href = "https://xueshu.baidu.com/s?wd=author: (Xu Tao) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Xu Tao , Zuo Zhiwei , Xia Xiaobo ,< a href = "https://xueshu.baidu.com/s?wd=author: (Dong Wei) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Dong Wei ,< a href = "https://xueshu.baidu.com/s?wd=author: (Chu Lingling) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Chu Lingling ,< a href = "https://xueshu.baidu.com/s?wd=author: (Liu Wenbo) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Liu Wenbo ,< a href = "https://xueshu.baidu.com/s?wd=author: (Hu Lin) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Hu Lin A href = "https://xueshu.baidu.com/s?wd=author: (Zou Ping) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Zou Ping , Chen Jun , Cao lei
Last Update：2024-01-02 23:10:35
