LOXIGLUMIDE

Name	LOXIGLUMIDE
Synonyms	CS-162 LOXIGLUMIDE LoxigluMide (CR1505) (+-)-4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxope 5-[amyl(3-methoxypropyl)amino]-4-[(3,4-dichlorobenzoyl)amino]-5-keto-valeric acid 4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid 4-[(3,4-dichlorophenyl)carbonylamino]-5-[3-methoxypropyl(pentyl)amino]-5-oxo-pentanoic acid
CAS	107097-80-3

Molecular Formula	C21H30Cl2N2O5
Molar Mass	461.38
Density	1.233±0.06 g/cm3(Predicted)
Melting Point	113-115℃
Boling Point	632.2±55.0 °C(Predicted)
Solubility	DMSO: ≥5mg/mL
Appearance	powder
Color	white to beige
pKa	pKa ~5(at 25℃)
Storage Condition	2-8°C
In vivo study	The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest).

Last Update：2024-01-02 23:10:35

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QQ: 3008007409

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LOXIGLUMIDE

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