Molecular Formula | C21H22F2N6O2 |
Molar Mass | 428.4352 |
Density | 1.55±0.1 g/cm3(Predicted) |
Solubility | DMSO: ≥ 4.6 mg/mL |
Appearance | morphological solid |
Color | Yellow |
pKa | 8.41±0.40(Predicted) |
Storage Condition | Room Temprature |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
Physical and Chemical Properties | Bioactive Larotrectinib (Vitrakvi, LOXO-101, ARRY-470) is a highly selective inhibitor of ATP-competitive, orally administered tropomyosin-related kinase (TRK) family receptors. |
Downstream Products | LOXO-101 (sulfate) |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.334 ml | 11.67 ml | 23.341 ml |
5 mM | 0.467 ml | 2.334 ml | 4.668 ml |
10 mM | 0.233 ml | 1.167 ml | 2.334 ml |
5 mM | 0.047 ml | 0.233 ml | 0.467 ml |
Solubility | Soluble in DMSO (up to 5 mg/ml). |