LY2090314
LY2090314
CAS: 603288-22-8
Molecular Formula: C28H25FN6O3
LY2090314 - Names and Identifiers
LY2090314 - Physico-chemical Properties
| Molecular Formula | C28H25FN6O3 |
| Molar Mass | 512.53 |
| Density | 1.55±0.1 g/cm3(Predicted) |
| Solubility | Soluble in DMSO, not in water |
| Appearance | powder |
| Color | yellow to orange |
| pKa | 7.41±0.60(Predicted) |
| Storage Condition | -20°C |
| Use | LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis. Pre-clinically LY2090314 i stabilizes β-catenin and enhances the efficacy of platinum based regimens. |
| Target | GSK-3α GSK-3β |
| In vitro study | LY2090314 selectively inhibited the activity by GSK-3 by blocking ATP binding. LY2090314 is capable of stabilizing β-catenin. LY2090314 monotherapy showed limited efficacy. LY3090314 enhances the efficacy of cisplatin and carboplatin on solid tumor cancer cell lines in vitro. LY2090314 selectively inhibits the activity by GSK-3 by blocking ATP binding. LY2090314 is capable of stabilizing β-catenin. LY2090314 monotherapy showed limited efficacy. LY3090314 enhances the efficacy of cisplatin and carboplatin on solid tumor cancer cell lines in vitro. |
| In vivo study | LY3090314 enhances the efficacy of cisplatin and carboplatin on solid tumor cancer cell lines in vitro. LY2090314 enhances the efficacy of cisplatin and carboplatin in xenografted solid tumors. |
LY2090314 - Reference
| Reference Show more | 1. Zamek-Gliszczynski MJ, et al. Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure. Dr2. Atkinson JM, et al. Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3. PLoS One. 2015 Apr 27;10(4):e0125028. |
LY2090314 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.951 ml | 9.756 ml | 19.511 ml |
| 5 mM | 0.39 ml | 1.951 ml | 3.902 ml |
| 10 mM | 0.195 ml | 0.976 ml | 1.951 ml |
| 5 mM | 0.039 ml | 0.195 ml | 0.39 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: LY2090314 Visit Supplier Webpage Request for quotationCAS: 603288-22-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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