Molecular Formula | C17H20N4S |
Molar Mass | 312.43 |
Density | 1.32±0.1 g/cm3(Predicted) |
Melting Point | 195°C |
Boling Point | 476.0±55.0 °C(Predicted) |
Flash Point | 2℃ |
Solubility | DMSO: >15mg/mL |
Vapor Presure | 0mmHg at 25°C |
Appearance | Pale yellow crystalline powder |
Color | yellow |
Merck | 14,6822 |
BRN | 7655141 |
pKa | 7.78±0.20(Predicted) |
Storage Condition | 2-8°C |
Sensitive | Sensitive to heat |
Refractive Index | 1.709 |
MDL | MFCD00866702 |
Physical and Chemical Properties | Crystallization from acetonitrile, melting point 195 °c. |
Use | For the control of schizophrenia, bipolar mania and other diseases |
Risk Codes | R36/38 - Irritating to eyes and skin. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
UN IDs | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
RTECS | XJ9007750 |
HS Code | 29349990 |
Hazard Class | 6.1 |
Packing Group | III |
First, it is necessary to select appropriate raw materials and excipients to prepare olanzapine. Commonly used raw materials include chlorpromazine, tolbutamide, nitrophenethyl ether, etc. Excipients can choose different ingredients according to different needs, such as starch, dextrin, magnesium stearate, etc.
Secondly, the raw materials and auxiliary materials are mixed together for mixing, grinding and other operations to make them fully mixed. In this step, attention should be paid to the control of temperature and time to avoid chemical changes or thermal decomposition of raw materials or excipients.
Next, put the mixture into the reaction kettle, add an appropriate amount of water or other solvents, stir evenly, and then heat or cool it. In the process of treatment, it is necessary to pay close attention to the reaction and adjust the reaction conditions in time to ensure the smooth progress of the reaction and obtain the required products.
Finally, the obtained product was filtered and dried to obtain olanzapine product. It should be noted that the humidity and temperature of the environment should be maintained during the drying process to avoid affecting the quality and stability of the product.
The preparation method of olanzapine needs to select appropriate raw materials and excipients, and carry out sufficient stirring, grinding and other operations to make them fully mixed. At the same time, attention should also be paid to controlling the reaction conditions and drying environment to ensure that the product quality and stability meet the requirements.