Luveniq
Voclosporin
CAS: 515814-01-4
Molecular Formula: C63H111N11O12
Luveniq - Names and Identifiers
Luveniq - Physico-chemical Properties
| Molecular Formula | C63H111N11O12 |
| Molar Mass | 1214.65 |
| Density | 1.016±0.06 g/cm3(Predicted) |
| Boling Point | 1303.8±65.0 °C(Predicted) |
| pKa | 13.32±0.70(Predicted) |
Luveniq - Uses and synthesis methods
biological activity
Voclosporin (ISAtx-247) is a calcineurin (CN; PP2B) inhibitor.
target
Calcineurin
in vitro study
This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro.
in vivo studies
All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively).
Last Update：2024-04-09 01:59:50
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Spot supply
Product Name: Voclosporin Visit Supplier Webpage Request for quotationCAS: 515814-01-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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