M-AMINOPHENOL
3-Aminophenol
CAS: 591-27-5
Molecular Formula: C6H7NO
M-AMINOPHENOL - Names and Identifiers
M-AMINOPHENOL - Physico-chemical Properties
| Molecular Formula | C6H7NO |
| Molar Mass | 109.13 |
| Density | 0.99 |
| Melting Point | 120-124 °C (lit.) |
| Boling Point | 164 °C/11 mmHg (lit.) |
| Flash Point | 155 °C |
| Water Solubility | 35 g/L (20 ºC) |
| Solubility | 26g/l |
| Vapor Presure | 0.019Pa at 20℃ |
| Appearance | Crystalline Powder |
| Color | White to pinkish or light gray |
| Odor | odorless |
| Merck | 14,460 |
| BRN | 636059 |
| pKa | 4.37, 9.82(at 20℃) |
| PH | 6.8 (10g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, bases, mineral acids. May be light or air-sensitive. |
| Refractive Index | 1.5444 (estimate) |
| Physical and Chemical Properties | Character: white crystal. melting point 123 ℃ boiling point 164 ℃ solubility: soluble in water, ethanol, ether, insoluble in benzene and gasoline. |
| Use | Dyes and pharmaceutical intermediates, used in the production of anti-tuberculosis drugs, aminosalicylic acid, stabilizers, developers, color films, etc. |
M-AMINOPHENOL - Risk and Safety
| Risk Codes | R20/22 - Harmful by inhalation and if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - |
| UN IDs | UN 2512 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SJ4900000 |
| TSCA | Yes |
| HS Code | 29222900 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 i.p. in mice: 4.5 mg/20g (Koelzer, Giesen) |
M-AMINOPHENOL - Upstream Downstream Industry
| Raw Materials | 3-Aminobenzene sulfonic acid Sulfuric acid 3-Aminobenzene sulfonic acid Potassium hydroxide Sodium hydroxide Nitrobenzene Hydrochloric acid |
M-AMINOPHENOL - Nature
Open Data Verified Data
white crystals. Boiling Point (1. 466 kPa)164 ℃. Melting point 123 °c. Soluble in water, ethanol, ether, difficult to benzene and gasoline.
Last Update：2024-01-02 23:10:35
M-AMINOPHENOL - Hair-making
Open Data Verified Data
nitrobenzene is sulfonated with fuming sulfuric acid, then reduced with iron powder, and then obtained by alkali fusion and acidification.
Last Update：2022-01-01 10:53:00
M-AMINOPHENOL - Use
Open Data Verified Data
for the production of antioxidants, stabilizers, developers, color films. In medicine for the preparation of anti-tuberculosis drug P-aminosalicylic acid. In the textile industry for printing and dyeing and fur, hair dyeing.
Last Update：2022-01-01 10:53:00
M-AMINOPHENOL - Safety
Open Data Verified Data
There are two toxic groups in the molecule of the amino phenol, so it has the double toxicity of aniline and phenol. Can be absorbed through the skin and cause dermatitis, can cause methemoglobin and asthma. Mouse oral LD50 4.5rng/kg.
Hermetically stored in a barrel lined with plastic bags to protect against heat and moisture. According to the provisions of the storage and transportation of highly toxic substances.
Last Update：2022-01-01 10:53:01
M-AMINOPHENOL - Reference Information
| Color index | 76545 |
| LogP | 0.183 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used as dye and pharmaceutical intermediates, for the manufacture of azo dyes for organic synthesis dyes and pharmaceutical intermediates for the production of anti-tuberculosis drugs, aminosalicylic acid, stabilizers, developers, color films. M-aminophenol is an intermediate of bactericide, rust-killing amine and fluoroamide. dye intermediate, used in the manufacture of azo dyes, can also be used for fur dyes, such as fur brown EG, fur yellow EG, etc. Pharmaceutical intermediates for the production of anti-TB drug P-aminosalicylic acid. Also used in the production of antioxidants, stabilizers, developers and color films, but also for hair dyeing. It is used as a pharmaceutical Intermediate, a photosensitive material, etc. organic synthesis. Dye and an intermediate of p-aminosalicylic acid. |
| production method | with M-aminobenzenesulfonic acid as raw material, it is obtained by alkali fusion and acidification. The M-aminobenzenesulfonic acid was stirred with water to form a slurry, heated to 60 ° C., the caustic soda solution was added dropwise to make the pH 7-8, and the M-aminobenzenesulfonic acid sodium salt solution was filtered. Put solid alkali or liquid alkali in the alkali melting pot, heat and melt or evaporate, and gradually add the m-aminobenzenesulfonic acid sodium salt solution at 275 ℃. After addition, the reaction was continued at 275 ℃ for 75min. The material was diluted in a sodium sulfite wash and the sodium sulfite was isolated by filtration. The sodium M-aminophenol solution after separation of the sodium sulfite was neutralized by adding 31% hydrochloric acid below 50 °c. The temperature is cooled to 35 ° C., the crude M-aminophenol is precipitated, filtered, the filter cake is added to the distillation Pan, vacuum distillation, and the distilled refined M-aminophenol is processed through the processing machine to obtain a sheet product. The yield was 60%. Industrial M-aminophenol is white crystal, melting point 119-123 ℃, content is more than or equal to 98%. The preparation method is to stir M-aminobenzenesulfonic acid with water to form a slurry, heat to 60 ℃, Dropwise add caustic soda solution (pH = 7~8), and filter to obtain m-aminobenzenesulfonic acid salt, the salt solution was slowly added to the concentrated caustic soda aqueous solution, and reacted at 270 ° C. Until Na2SO3 was no longer formed, diluted with water and filtered, and the Na2SO3 residue was separated, Then dilute the alkali solution with hot water, keep the dilution temperature at 100~110 ℃ and perform hot filtration. Acidify the filtrate with 30% industrial hydrochloric acid, the temperature is not higher than 90 ℃, and the end pH of acidification is 7~8, after acidification, it is cooled to below 20 ℃, allowed to stand, crystallized, filtered, and then subjected to vacuum distillation to obtain the finished product. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 924 mg/kg; Oral-mouse LD50: 401 mg/kg |
| stimulation data | Skin-rabbits 12.5 mg/24 h mild; eye-rabbit 100 mg/24 h moderate |
| flammability hazard characteristics | open flame flammability; Thermal decomposition of toxic nitrogen oxides and chloride gases |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | carbon dioxide, sand, foam, water mist, dry powder |
| Occupational Standard | sel 1 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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Raw Materials for M-AMINOPHENOL