MACROFUSINE
Fumonisin B1
CAS: 116355-83-0
Molecular Formula: C34H59NO15
MACROFUSINE - Names and Identifiers
| Name | Fumonisin B1 |
| Synonyms | MACROFUSINE Fumonisin B1 Standard Solution Fumonisin B1 1,2,3-propanetricarboxylicacid,1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltr 1,2,3-PROPANETRICARBOXYLIC ACID 1,1'-[1-(12-AMINO-4,9,11-TRIHYDROXY-2-METHYLTRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANEDIYL] ESTER |
| CAS | 116355-83-0 |
| EINECS | 621-436-3 |
MACROFUSINE - Physico-chemical Properties
| Molecular Formula | C34H59NO15 |
| Molar Mass | 721.83 |
| Density | 1.2207 (rough estimate) |
| Melting Point | >60oC |
| Boling Point | 713.81°C (rough estimate) |
| Flash Point | 6 °C |
| Solubility | Soluble in Water (up to 25 mg/ml). |
| Appearance | Morphology Powder |
| Color | White to tan |
| pKa | 3?+-.0.23(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
| Refractive Index | 1.6630 (estimate) |
| Physical and Chemical Properties | Bioactive Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase), disrupting the de novo biosynthesis of sphingolipids. Fumonisin B1 is the most abundant and toxic fumonisin. |
MACROFUSINE - Risk and Safety
| Risk Codes | R40 - Limited evidence of a carcinogenic effect R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3172 |
| WGK Germany | 3 |
| RTECS | TZ8350000 |
| HS Code | 29221990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
MACROFUSINE - Reference
| Reference Show more | 1. He, Baoshan, and Xiaoze Dong. "Aptamer based voltammetric patulin assay based on the use of ZnO nanorods." Microchimica Acta 185.10 (2018): 1-8.https://doi.org/10.1007/s00604-018-3006-0 2. Baoshan He, Xiaohai Yan, A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone, Sensors and Actuators B: Chemical, Volume 290, 2019, Pages 477-483, ISSN 0925-4005, https://doi.org/10.1016/j 3. [IF=6.057] Yongmei Jia et al."A label-free fluorescent aptasensor for the detection of Aflatoxin B1 in food samples using AIEgens and graphene oxide."Talanta. 2019 Jun;198:71 4. [IF=5.833] He Baoshan et al."Aptamer based voltammetric patulin assay based on the use of ZnO nanorods."Microchim Acta. 2018 Oct;185(10):1-8 5. [IF=7.46] Baoshan He et al."A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone."Sensor Actuat B-Chem. 2019 Jul;290:477 6. [IF=7.46] Long Wang et al."A DNAzyme-assisted triple-amplified electrochemical aptasensor for ultra-sensitive detection of T-2 toxin."Sensor Actuat B-Chem. 2021 Feb;328:129063 7. [IF=5.373] Han Yan et al."A label-free electrochemical immunosensing platform based on PEI-rGO/Pt@Au NRs for rapid and sensitive detection of zearalenone."Bioelectrochemistry. 2022 Feb;143:107955 |
MACROFUSINE - Nature
| (IARC) Carcinogen Classification | 2B (Vol. 56) 1993, 2B (Vol. 82) 2002 |
Last Update：2024-04-10 22:29:15
MACROFUSINE - Uses and synthesis methods
background
fumonisin (Fumonisin,Macrofusine) mainly occurs in corn, including at least 15 similar toxins, of which fumonisin B1(Fumonisin B1,FB1) is the most important. Although fumotoxin was discovered to have an effect on horses 150 years ago, the official identification was still in the mid-2080s. Fumonisin is a polar metabolite of several Fusarium species (Fusarium Moniliforme). Its basic structure is a long-chain hydroxy hydrocarbon chain containing methyl and amino groups. The two hydroxyl groups are esterified onto the two propyl-1, 2, 3-tricarboxylic acids.
Target
Sphingosine N-acyltransferase
in vitro studies
Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells.
Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes.
category
Toxic substances
Toxicity classification
Highly toxic
Acute toxicity
Oral-Monkey TDL0: 1 mg/kg
flammability hazard characteristics
Flammable, hot and irritating smoke from the fire site
storage and transportation features
The warehouse is low temperature, ventilated and dry; stored separately from food ingredients
Fire extinguishing agent
Water, carbon dioxide, dry powder, sand
Last Update：2024-04-10 22:29:15
Supplier List
Multiple Specifications
Product Name: Fumonisin B1 Visit Supplier Webpage Request for quotationCAS: 116355-83-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: Fumonisin B1 Visit Supplier Webpage Request for quotationCAS: 116355-83-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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