MAL3-101 - Names and Identifiers
| Name | 5-PyriMidinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-Methyl-2-oxo-, phenylMethyl ester
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| Synonyms | MAL3-101
benzyl 4-([1,1'-biphenyl]-4-yl)-1-(6-((2-(butylamino) -1-(4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl)-2-oxoethyl)(hexyl)amino)-6-oxohexyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
5-PyriMidinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-Methyl-2-oxo-, phenylMethyl ester
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| CAS | 831217-40-4
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MAL3-101 - Physico-chemical Properties
MAL3-101 - Upstream Downstream Industry
MAL3-101 - Introduction
5-PyriMidinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-Methyl-2-oxo-, phenylMethyl ester (5-PyriMidinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3,4-tetrahy dro-6-Methyl-2-oxo-, phenylMethyl ester), also known as Palbociclib, is an anti-cancer drug.
Nature:
chemical formula: C24H29N7O4S
Molecular weight: 507.6g/mol
Appearance: white or white crystalline powder
Melting point: about 160-162 ° C
Solubility: Good solubility in solvents, for example, high solubility in dimethyl sulfoxide and methylene chloride.
Use:
5-PyriMidinecarboxylic acid, 4-[1,1 '-biphenyl]-4-yl-1-[6-[[2-(butylaMino)-1-[3-(Methoxycarbonyl))-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3-, phenylMethyl ester is a CDK4/6 (cyclin-regulated protein kinase 4/6) inhibitor used as a chemotherapeutic agent for breast cancer and other malignancies. It blocks cell cycle progression and inhibits the growth and spread of cancer cells.
Method:
Accurate preparation methods may require specific chemical laboratory conditions and expertise, so only a simplified summary route is provided here. The specific preparation method is as follows:
1. First, 5-PyriMidinecarboxylic acid, 4-[1,1 '-biphenyl]-4-yl-1-[6-[[2-(butylaMino)), was synthesized by a multi-step reaction -1-[3-(Methoxycarbonyl)-4-(2-Methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylaMino]-6-oxohexyl]-1,2,3, phenyl-, the precursor compound of phenylMethyl ester.
2. The precursor compound is reacted with an appropriate substituent compound to form the target compound.
Safety Information:
Follow strict laboratory procedures when using and handling drug compounds. Palbociclib is mainly used in the medical field and should be used under the guidance of a physician. Follow relevant laws and regulations and medical guidance when using.
Last Update：2024-04-09 21:01:54