Molecular Formula | C11H15N2O4PS |
Molar Mass | 302.29 |
Density | 1.47±0.1 g/cm3(Predicted) |
Boling Point | 576.7±60.0 °C(Predicted) |
pKa | 0.98±0.10(Predicted) |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.308 ml | 16.54 ml | 33.081 ml |
5 mM | 0.662 ml | 3.308 ml | 6.616 ml |
10 mM | 0.331 ml | 1.654 ml | 3.308 ml |
5 mM | 0.066 ml | 0.331 ml | 0.662 ml |
biological activity | MB05032 is a GNG inhibitor that targets the AMP-binding site of fructose -1, 6-bisphosphatase, the IC50 was 16 nM. |
Target | IC50: 16 nM (Human Liver FBPase) |
Animal Model: | ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes)) |
Dosage: | 3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats) |
Administration: | Oral administration; once |
Result: | Results in dose-dependent glucose lowering. |