Molecular Formula | C17H22Cl2N2O3S
|
Molar Mass | 405.34 |
Density | 1.34±0.1 g/cm3(Predicted) |
Boling Point | 643.4±55.0 °C(Predicted) |
pKa | 10.21±0.10(Predicted) |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | Bioactivity K-Ras(G12C) inhibitor 6 is an allosteric, selective tumorigenic K-Ras(G12C) inhibitor. |
Target | Target Value K-Ras(G12C) (Cell-free assay) |
In vitro study | K-Ras(G12C) inhibitor 6 belongs to a series of small molecules capable of irreversibly binding to a common oncogenic mutant K-Ras(G12C) and blocking the interaction of K-Ras(G12C). Some of these K-Ras(G12C) inhibitors 6 reduce the activity of G12C-cancer cell lines and increase their apoptosis. |