MDK36122
HPGDS inhibitor 1
CAS: 1033836-12-2
Molecular Formula: C19H19F4N3O
MDK36122 - Names and Identifiers
MDK36122 - Physico-chemical Properties
| Molecular Formula | C19H19F4N3O |
| Molar Mass | 381.37 |
| Solubility | 10 mM in DMSO |
| Storage Condition | 2-8°C |
| In vitro study | HPGDS inhibitor 1 has equal potency against purified HPGDS from human, rat, dog, and sheep (IC 50 , 0.5-2.3 nM). |
| In vivo study | HPGDS inhibitor 1 (compound 8; 1 mg/kg) has excellent PK characteristics with 76% bioavailability, and the T 1/2 is 4.1 hours in rats. Rats dosed orally with 1 mg/kg and 10 mg/kg HPGDS inhibitor 1 (compound 8) are sacrificed at various times. Oral administration of HPGDS inhibitor 1 blocks PGD2 production in the rat spleen; inhibition of PGD2 is inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time- and dose-dependent manner. HPGDS inhibitor 1 (compound 8; 1 mg/mL) illustrates efficacy in an in vivo sheep model of asthma. |
MDK36122 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.622 ml | 13.111 ml | 26.221 ml |
| 5 mM | 0.524 ml | 2.622 ml | 5.244 ml |
| 10 mM | 0.262 ml | 1.311 ml | 2.622 ml |
| 5 mM | 0.052 ml | 0.262 ml | 0.524 ml |
Last Update：2024-01-02 23:10:35
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Product Name: HPGDS inhibitor 1 Visit Supplier Webpage Request for quotationCAS: 1033836-12-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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