MDK6314
STAT5-IN-1
CAS: 285986-31-4
Molecular Formula: C16H11N3O3
MDK6314 - Names and Identifiers
| Name | STAT5-IN-1 |
| Synonyms | MDK6314 CS-2509 STAT5-IN-1 STAT5 Inhibitor STAT5 Inhibitor 1 N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide 3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide |
| CAS | 285986-31-4 |
| EINECS | 604-604-1 |
MDK6314 - Physico-chemical Properties
| Molecular Formula | C16H11N3O3 |
| Molar Mass | 293.28 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 214-216 °C |
| Solubility | DMSO: ≥23.0 mg/mL |
| pKa | 10.44±0.46(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members. |
MDK6314 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.41 ml | 17.049 ml | 34.097 ml |
| 5 mM | 0.682 ml | 3.41 ml | 6.819 ml |
| 10 mM | 0.341 ml | 1.705 ml | 3.41 ml |
| 5 mM | 0.068 ml | 0.341 ml | 0.682 ml |
Last Update：2024-01-02 23:10:35
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Product Name: STAT5-IN-1 Visit Supplier Webpage Request for quotationCAS: 285986-31-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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