METHANOL-D3OH
Methanol-d3
CAS: 1849-29-2
Molecular Formula: CHD3O
METHANOL-D3OH - Names and Identifiers
| Name | Methanol-d3 |
| Synonyms | METHANOL-D3 Methanol-d3 METHAN-D3-OL METHANOL-D3OH METHYL-D3 ALCOHOL TETRADEUTEROMETHANOL |
| CAS | 1849-29-2 |
| EINECS | 217-435-9 |
METHANOL-D3OH - Physico-chemical Properties
| Molecular Formula | CHD3O |
| Molar Mass | 35.06 |
| Density | 0.867 g/mL at 25 °C (lit.) |
| Melting Point | 174-177 °C |
| Boling Point | 65 °C (lit.) |
| Flash Point | 52 °F |
| Appearance | Liquid |
| Color | Colorless |
| BRN | 1732010 |
| Storage Condition | Flammables area |
| Explosive Limit | 5.5-36.5%(V) |
| Refractive Index | n20/D 1.327(lit.) |
METHANOL-D3OH - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/25 - Toxic by inhalation and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 1230 3/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 28459000 |
METHANOL-D3OH - Upstream Downstream Industry
| Raw Materials | Dimethoxymethylphenylsilane |
| Downstream Products | DIMETHYL-D6 SULFATE |
METHANOL-D3OH - Uses and methods of synthesis
Overview
Deuterated methanol (methanol-D3) is an important chemical raw materials and deuterated drug intermediates. The structure shown by the perdeuterated methanol (methanol-D3): CD3OD. In chemical synthesis, it is a commonly used nuclear magnetic resonance hydrogen spectrum detection reagent, which is widely used in experimental research work. In recent years, deuterated drugs have become a hot spot in drug research, and Deuterated methanol has been widely used in the research of deuterated drugs.
preparation
The preparation method of perdeuterated methanol (methanol-D3), specifically: open the valve of deuterium gas and carbon monoxide, and control the volume ratio of 1:1 premixed (deuterium and carbon monoxide were 2kg and 14kg, a total of 16kg). Through a catalyst bed of oxidized gold: platinum oxide: Rhodium oxide = 1:3:2 (mass ratio) at 210-380°C at a pressure of MPA at a rate of 2L/sec, after 24 hours of continuous circulation reaction, the reaction solution of whole Deuterated methanol (methanol-D3) was obtained in the separation kettle, and the obtained reaction solution was subjected to rectification to obtain whole Deuterated methanol (methanol-D3):3.2, yield 35.5%,GC purity 99.8%. Theoretical values of elemental analysis: C 33.30%, D 22.34%, O 44.36%; Measured values: C 33.32%, D 22.33%, O 44.35%.
Last Update：2024-04-10 22:29:15
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Raw Materials for METHANOL-D3OH
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