METHYCLOTHIAZIDE

Name	Methyclothiazide
Synonyms	Enduron Aquatensen methyclothiazid METHYCLOTHIAZIDE Methyclothiazide methychlothiazide methycyclothiazide 2-methyl-,1,1-dioxide 2-methyl-3-chloromethylhydrochlorothiazide 4-benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2h-2 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2h-1,2,4-benzothiadiazine-7-sul 6-chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 6-chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
CAS	135-07-9
EINECS	205-172-2
InChI	InChI=1/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16)

Molecular Formula	C9H11Cl2N3O4S2
Molar Mass	360.24
Density	1.6122 (rough estimate)
Melting Point	225°
Boling Point	597.9±60.0 °C(Predicted)
Flash Point	315.4°C
Water Solubility	50mg/L(room temperature)
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	2.93E-14mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	9.4(at 25℃)
Storage Condition	Refrigerator
Refractive Index	1.6000 (estimate)
In vitro study	Methylclothiazide (0.1 mM) reduces Ca methylclothiazide (0.1 mM) Intima-dependent inhibition of the vasoconstrictive response of the aorta to NE and AVP in spontaneously hypertensive rats (SHR), relative to normotensive Wistar Kyoto rats (WKY), the maximal vasoconstrictor effect of NE and AVP decreased by 59% and 32.3, respectively. Methyclothiazide (3.5 mM) inhibits renin release in rat kidney slices.
In vivo study	Methylclothiazide (0.1g/L for the first 5 weeks and 0.2g/L for the next 2 weeks in drinking water) attenuates the development of hypertension in salt-sensitive (DS) rats, but did not affect the blood pressure of salt-tolerant (DR) rats. At Weeks 3 and 4, methylclothiazide-treated DOCA-salt rats had lower body weights than control or unsupplemented DOCA-salt rats. Methylclothiazide was added to the drinking water of DOCA-salt rats to attenuate the increase in blood pressure.

HS Code

2935904000

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
application	methylchlorothiazide is a thiazide diuretic. It is clinically used for various edema, various stages of hypertension and diabetes insipidus. It is often combined with antihypertensive drug Disheping to treat hypertension.
indications	this product acts with hydrochlorothiazide. It is suitable for the treatment of various edema, and has a good effect on cardiogenic edema. It is also used to treat various stages of hypertension and diabetes insipidus.
Biological activity	Methyclothiazide is a thiazide diuretic that can inhibit norepinephrine-induced contractile response, which is mediated by endothelial cell-dependent mechanisms, including the release of vascular endothelium-dependent relaxation factor (EDRF) and nitric oxide (NO).
target	IC50: voltage-dependent Ca-channel (VDCC)
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-10 22:29:15

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