MKT-077
MKT 077
CAS: 147366-41-4
Molecular Formula: C21H22ClN3OS2
MKT-077 - Names and Identifiers
MKT-077 - Physico-chemical Properties
| Molecular Formula | C21H22ClN3OS2 |
| Molar Mass | 432.00188 |
| Solubility | H2O: soluble10mg/mL, clear |
| Appearance | powder |
| Color | orange to red |
| Storage Condition | 2-8°C |
| In vitro study | MKT-077 is a rhodacyanine dye and also a heat shock protein 70 (Hsp70) inhibitor which exhibits significant antitumor activity. MKT-077 treatment (0.1 to 10 µM dose ranges) for 48 hours can effectively decrease TT cell viability. MKT-077 treatment results in accumulation of cells in the G0/G1 phase in a dose-dependent manner, and also increases sub-G0/G1 phase population in TT cell culture in a dose-dependent manner. MKT-077 also downregulates cellular levels of the proliferation marker, Ki67, and the S-phase transcription factor, E2F-1, in TT and MZ-CRC-1 cells. Moreover, flow cytometry using different doses of MKT-077 reveales that TT cells can uptake and retain MKT-077 at significantly higher levels than MZ-CRC-1 cells. MKT-077 has EC 50 values of 1.4±0.2 and 2.2±0.2 μM against MDA-MB-231 and MCF7 breast cancer cells, respectivelyl. |
| In vivo study | Systemic administration of MKT-077 significantly delays the growth of TT xenografts in mice throughout the treatment. At the end of MKT-077 treatment, it is found that tumor weights are about two-times less in MKT-077-treated group than in control group. MKT-077 treatment also results in weight loss and general toxicity in animals. Results show that the succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls. |
MKT-077 - Risk and Safety
| WGK Germany | 3 |
| RTECS | UU4023332 |
| Toxicity | LD50 intraperitoneal in mouse: 50mg/kg |
MKT-077 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.315 ml | 11.574 ml | 23.148 ml |
| 5 mM | 0.463 ml | 2.315 ml | 4.63 ml |
| 10 mM | 0.231 ml | 1.157 ml | 2.315 ml |
| 5 mM | 0.046 ml | 0.231 ml | 0.463 ml |
Last Update：2024-01-02 23:10:35
MKT-077 - Reference Information
| biological activity | MKT-077 (FJ-776) is a new type, the complex cyanine dye with high water solubility has significant anti-tumor activity in various models. |
Last Update：2024-04-09 21:11:58
Supplier List
Spot supply
Product Name: MKT 077 Visit Supplier Webpage Request for quotationCAS: 147366-41-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: MKT 077 Visit Supplier Webpage Request for quotationCAS: 147366-41-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History