Molecular Formula | C19H19NO3 |
Molar Mass | 309.36 |
Density | 1.17±0.1 g/cm3(Predicted) |
Boling Point | 535.5±45.0 °C(Predicted) |
pKa | 3.93±0.10(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC 50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.232 ml | 16.162 ml | 32.325 ml |
5 mM | 0.646 ml | 3.232 ml | 6.465 ml |
10 mM | 0.323 ml | 1.616 ml | 3.232 ml |
5 mM | 0.065 ml | 0.323 ml | 0.646 ml |
biological activity | ML-098(CID-7345532) is an activator of the GTP binding protein Rab7 with an EC50 value of 77.6nM. |
Target | EC50: 77.6 nM (Rab7) |