ML-128
VU 0361737
CAS: 1161205-04-4
Molecular Formula: C13H11ClN2O2
ML-128 - Names and Identifiers
ML-128 - Physico-chemical Properties
| Molecular Formula | C13H11ClN2O2 |
| Molar Mass | 262.69 |
| Solubility | DMSO: soluble15mg/mL (clear solution) |
| Appearance | film |
| Color | white |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD16618402 |
| Use | VU0361737 |
| In vitro study | VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. |
| In vivo study | VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1). |
ML-128 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
ML-128 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.807 ml | 19.034 ml | 38.068 ml |
| 5 mM | 0.761 ml | 3.807 ml | 7.614 ml |
| 10 mM | 0.381 ml | 1.903 ml | 3.807 ml |
| 5 mM | 0.076 ml | 0.381 ml | 0.761 ml |
Last Update：2024-01-02 23:10:35
ML-128 - Reference Information
| biological activity | VU 0361737 is a selective (PAM)mGlu4 receptor positive allosteric modulator (PAM), which acts on human and rat receptors. EC50 is 240 nM and 110 nM respectively. It has weak activity on mGlu5 and mGlu8 receptors and inhibits mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptor activity, can penetrate into the CNS. |
| in vitro study | VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. |
| in vivo study | VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1). |
| target | human mGlu 4 240 nM (EC 50 ) Rat mGlu 4 110 nM (EC 50 ) |
Last Update：2024-04-09 20:52:54
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Product Name: VU 0361737 Visit Supplier Webpage Request for quotationCAS: 1161205-04-4
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Spot supply
Product Name: VU 0361737 Visit Supplier Webpage Request for quotationCAS: 1161205-04-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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