ML297
ML297
CAS: 1443246-62-5
Molecular Formula: C17H14F2N4O
ML297 - Names and Identifiers
ML297 - Physico-chemical Properties
| Molecular Formula | C17H14F2N4O |
| Molar Mass | 328.32 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Boling Point | 377.8±42.0 °C(Predicted) |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | White powder |
| Color | white to beige |
| pKa | 12.54±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | ML 297 is completely inactive for GIRK 2/3 . ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC 50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK 2 alone and GIRKGIRK 2/3 . |
| In vivo study | ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment. Animal Model: 8-10 months old C57/BL6 male mice (approximately 30 g) Dosage: 60 mg/kg Administration: Intraperitoneal injection Result: Most of the animals neither convulsions nor death. |
ML297 - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
ML297 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.046 ml | 15.229 ml | 30.458 ml |
| 5 mM | 0.609 ml | 3.046 ml | 6.092 ml |
| 10 mM | 0.305 ml | 1.523 ml | 3.046 ml |
| 5 mM | 0.061 ml | 0.305 ml | 0.609 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: ML297 Visit Supplier Webpage Request for quotationCAS: 1443246-62-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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