Name | ML324 |
Synonyms | ML243 ML234 ML324 ML 324 ML-324 CS-2198 NCGC00183808-01 ML324(CID-44143209) N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide |
CAS | 1222800-79-4 |
Molecular Formula | C21H23N3O2 |
Molar Mass | 349.43 |
Density | 1.188±0.06 g/cm3(Predicted) |
Melting Point | >187oC (dec.) |
Boling Point | 590.1±50.0 °C(Predicted) |
Solubility | DMSO: ≥ 33 mg/mL |
Appearance | powder |
Color | white to light brown |
pKa | 4.71±0.40(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
In vitro study | ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression. |
In vivo study | In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.862 ml | 14.309 ml | 28.618 ml |
5 mM | 0.572 ml | 2.862 ml | 5.724 ml |
10 mM | 0.286 ml | 1.431 ml | 2.862 ml |
5 mM | 0.057 ml | 0.286 ml | 0.572 ml |