MLS-50
Lactulose
CAS: 4618-18-2
Molecular Formula: C12H22O11
MLS-50 - Names and Identifiers
MLS-50 - Physico-chemical Properties
| Molecular Formula | C12H22O11 |
| Molar Mass | 342.3 |
| Density | 1,32g/cm |
| Melting Point | ~169°C (dec.) |
| Boling Point | 397.76°C (rough estimate) |
| Specific Rotation(α) | -47 º (C=5, H2O, 12HR) |
| Flash Point | 291.9°C |
| Water Solubility | 76.4 G/100 ML (30 ºC) |
| Solubility | Soluble in water, solubility in water: 76.4% (30°C) |
| Vapor Presure | 2.43E-28mmHg at 25°C |
| Appearance | White solid |
| Color | White to almost white |
| Merck | 5346 |
| BRN | 93773 |
| pKa | 11.67±0.20(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1,45-1,47 |
| MDL | MFCD00151469 |
| Physical and Chemical Properties | Light yellow transparent viscous liquid (content of more than 50%), cool and sweet, sweetness of sucrose 48% ~ 62%. Combined with sucrose, sweetness can be increased. Relative density 1.35, refractive index 1.47. Soluble in water, the solubility in water is 70%(25 C). Mouse oral LD5021.5g/kg, rat oral LD5047.2g/kg. |
| Use | Reduce blood ammonia and laxative effect, mainly used for the treatment of ammonia hepatic coma, high blood ammonia and habitual constipation and other diseases |
MLS-50 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | LS6965000 |
| TSCA | Yes |
| HS Code | 29400090 |
MLS-50 - Reference
| Reference Show more | 1. Wang Ruiming. Effects of Ulinastatin on intestinal permeability and bacterial translocation in ventilator-associated Pneumonia model rats [J]. Zhejiang Journal of Integrated Traditional Chinese and Western medicine 2018 028(007):530-532. 2. Wang Ruiming. Effect of acute abdomen No. Ⅲ on small intestinal morphology of ventilator-associated Pneumonia rats [J]. Modern doctor of China, 2018,56(03):30-33. 3. Wang Ruiming. Effect of acute abdomen No. Ⅲ on intestinal permeability and bacterial translocation in ventilator-associated Pneumonia rats [J]. Modern doctor of China, 2017(34). 4. Wang Ruiming, Ye Yuanling. Effect of acute abdomen No. Ⅲ on intestinal mucosal barrier in ventilator-associated Pneumonia rats [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 033(011):5220-5222. 5. Wang Jianming, Jia Xiaoyang, et al. Effects of Lactobacillus casei SY13 and its synbiotics on the abundance of Akkermansia muciniphila in the intestine of mice [J]. Science and Technology of food industry, 2018, 039(010):308-314. 6. Zhu Xiaofeng, Zhang Zhen, Cui LeiHong, Zhu Weiyun, hang Suqin. Combination screening and in vitro fermentation characteristics of Lactobacillus and prebiotics from swine [J]. Journal of Microbiology, 2021,61(01):104-114. |
MLS-50 - Nature
Open Data Verified Data
light yellow transparent viscous liquid, cool and sweet, sweetness of sucrose 48% ~ 62%. Soluble in water, solubility in water (30qC)76. 4%, (60 ° C) 81%, (90 ° C)>86%. With sucrose, sweetness can be increased.
Last Update：2024-01-02 23:10:35
MLS-50 - Preparation Method
Open Data Verified Data
results from isomerization of lactose by alkali.
Last Update：2022-01-01 10:10:31
MLS-50 - Use
Open Data Verified Data
isomerized lactose is not absorbed by human body, but it can promote the proliferation of intestinal Bifidobacterium, which is beneficial to health. China's regulations (all based on isomerized lactose dry matter) can be used for milk powder, the maximum use of 15g/kg; The maximum use in biscuits 2. Og/kg; Maximum usage in beverages (liquid, solid) and fresh milk 1. 5g/kg.
Last Update：2022-01-01 10:10:32
MLS-50 - Concentrated lactulose solution
Authoritative Data Verified Data
This product is an aqueous solution of lactulose. Lactulose (C12H22O1) should be 63.0% to 73.0% (g/m l).
trait
This product is colorless to light brown yellow clear viscous liquid.
identification
- take 5% aqueous solution of this product and slowly drop 5ml of warm alkaline copper tartrate solution to generate red cuprous oxide precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- relative density the relative density of this product (General 0601) is 1.260~1.390.
- the pH value should be 3.0 to 7.0. Take this product and the electrode contact 15 minutes after the determination (General 0631).
- the color of the solution of this product, according to UV-visible spectrophotometry (General 0401), with water as the blank, at the wavelength of 420nm absorbance measurement, not over 0.5.
- The test solution under the item of content determination of related substances is the test solution I. The appropriate amount of lactulose, fructose, galactose and lactose reference substances are separately taken and precisely weighed, acetonitrile-water (1:1) was added, dissolved and quantitatively diluted to prepare a mixed solution containing 3.2mg, 0.4mg, 4.8mg, and 4mg per 1 ml, as a control solution. According to the chromatographic conditions under the content determination item, accurately measure 20ul of the reference solution and the test solution, respectively inject the human liquid chromatograph, record the chromatogram, in the chromatogram of the test solution, if there are chromatographic peaks consistent with the retention time of fructose, galactose and lactose, the peak area shall be calculated according to the external standard method, and the contents of fructose, galactose and lactose shall not exceed the l content of lactulose. O% ,15.0% and 10.0%; If there are chromatographic peaks (tagatose) at about 0.9 of the retention time relative to the fructose peak or if there is a chromatographic peak (eipilactose) at a retention time of about 0.9 relative to the peak of lactulose, calculated by the area of the peak of lactulose in the solution of the reference substance according to the external standard method, 4.0% and 10.0% of the lactulose content shall not be exceeded, respectively.
- ignition residue 1.5g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed 0.1%.
- the residue left under the item of heavy metal extraction and ignition residue shall be inspected according to law (General Principles 0821, second law), and the content of heavy metal shall not exceed 20 parts per million.
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test with aminopropylsilane bonded silica gel as filler, acetonitrile-phosphate buffer (take sodium dihydrogen phosphate 1.15g, dissolved in water)(84:16) the mobile phase was measured with a refractive index detector, column temperature and cell temperature were both 40°C, and flow rate was 1.5ml per minute. Take the appropriate amount of lactulose, fructose, galactose and lactose respectively, and add acetonitrile-water (1:1) solution to make a mixed solution containing 40mg, 0.4mg, 4.8mg and 4mg per 1 ml, measure 20 u1, inject human liquid chromatograph, the peak order is fructose, galactose, lactulose and lactose, the signal-to-noise ratio of fructose peak height should be greater than 10, the resolution between lactulose peak and lactose peak should be greater than 2.0.
- determination of this product, (about equivalent to lactulose lg ), Precision weighing, put in 25ml measuring flask, add acetonitrile-water (1:1) solution to dissolve and dilute to the scale, shake well, as a test solution, take 20 u1 with precision, inject it into liquid chromatograph, record the chromatogram; Take the reference substance of lactulose with precision, measure it with the same method, and calculate it by peak area according to external standard method.
category
blood ammonia and laxative drugs.
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:36:48
MLS-50 - Duphalac (Lactulose Oral Solution)
Authoritative Data Verified Data
This product is a sterile aqueous solution of lactulose. Lactulose (C12H22O11), 90.0%-110.0% of labeled amount.
trait
This product is colorless to light brown yellow clear viscous liquid.
identification
- take 5% aqueous solution of this product and slowly drop 5ml of warm alkaline copper tartrate solution to generate red cuprous oxide precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- relative density the relative density of this product (General 0601) is 1.260~1.390.
- the pH value should be 3.0 to 7.0. Measurements were made after 15 minutes of contact with the electrode (General 0631).
- the color of the solution of this product, according to UV-visible spectrophotometry (General 0401), with water as the blank, at the wavelength of 420nm absorbance measurement, not over 0.5.
- The test solution under the item of content determination is taken as the test solution; The appropriate amount of lactulose, fructose, galactose and lactose are taken respectively for precision weighing, an acetonitrile-water (1:1) solution was added, dissolved and quantitatively diluted to prepare a mixed solution containing 3.2mg, 0.4mg, 4.8mg, and 4mg per 1 ml, respectively, as a control solution. According to the chromatographic conditions under the content determination item, 20ul of each of the reference solution and the test solution is accurately measured, and the human liquid chromatograph is injected respectively, and the chromatogram is recorded. In the chromatogram of the test solution, if there are chromatographic peaks of fructose, galactose and lactose, the peak area shall be calculated according to the external standard method, and the contents of fructose, galactose and lactose shall not exceed 1.0% of the labeled amount of lactulose respectively, 15.0% and 10.0%; If there is a chromatographic peak at about 0.9 relative to the fructose peak retention time (tagatose) or if there is a chromatographic peak at about 0.9 relative to the lactulose peak retention time (elipilactose), according to the external standard method, the peak area of lactulose in the reference solution shall not exceed 4.0% and 10.0% of the labeled amount of lactulose, respectively.
- the residue left under the item of taking heavy metals for burning residues shall be inspected according to law (General Principles 0821, second law), and the content of heavy metals shall not exceed 20 parts per million.
- ignition residue 1.5g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed 0.1%.
- others should comply with the relevant provisions under the item of oral solution (General rule 0123).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test with aminopropylsilane bonded silica gel as filler; Acetonitrile-phosphate buffer (take sodium dihydrogen phosphate 1.15g, dissolved in water)(84:16) for mobile phase; Determination by refractive index detector, column temperature and detection cell temperature are 40°C, flow rate of 1.5 ml per minute, respectively, take the right amount of lactulose, fructose, galactose, lactose reference, add acetonitrile-water (1:1) solution to make mixed solution containing 40mg, 0.4mg, 4.8mg, 4mg in each 1 ml, take 20 u1, inject human liquid chromatograph, the order of peak emergence was fructose, galactose, lactulose and lactose. The signal-to-noise ratio of fructose peak height should be greater than 10, and the separation degree between lactulose peak and lactose peak should be greater than 2.0.
- determination: take an appropriate amount of this product (about equivalent to lg of lactulose), weigh it accurately, put it in a 25ml measuring flask, add acetonitrile-water (1:1) solution to dissolve and dilute to the scale, shake, as a test solution, precise injection liquid chromatograph, record chromatogram; Another lactulose control, the same method for determination. According to the external standard method to calculate the peak area, that is.
category
blood ammonia and laxative.
specification
(l)10ml:5g (2) 100ml:50g (3)100ml:66.7g
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:36:49
MLS-50 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| background and overview | since pettler discovered that lactulose is a Bifidobacterium proliferation factor in 1957, Hoffman also discovered that only Bifidobacterium, Lactobacillus and LD streptococcus can make lactulose produce lactic acid and acetic acid in 1964, which is the first to clarify the metabolic process of lactulose bacteria. In 1966, Bertzil discovered that taking lactulose can promote the growth of basophilic gram-positive bacteria (E. coli, etc.) that lack urease and reduce the production of ammonia. Repeated clinical trials have verified that lactulose has the effect of reducing blood ammonia. It is used to treat hepatic encephalopathy successfully. In 1979, Mollayu used lactulose to treat viral hepatitis. He found that it had the effect of lowering plasma endotoxin. From 1980 to 1981, Rezel discovered that lactulose can inhibit the limulus test agglutination reaction of endotoxin in vitro, and reduce the liver injury of rats caused by D-galactosamine. It is believed that lactulose has anti-endotoxin activity and is used to treat liver and kidney syndrome. The clinical application in my country was Professor Tian Gonshan from Beijing Medical University in 1982. He has a leading position in the clinical application of lactulose. He emphasized that lactulose varies from person to person and keeps patients soft stool 2-3 times a day. The prevention and treatment of recurrent hepatic encephalopathy should be used for a long time. For chronic hepatitis medication, it can reduce the absorption of ammonia and endotoxin, increase the protein intake of patients with severe hepatitis and liver cirrhosis, and help patients recover health as soon as possible. In 1984, Professor Li Ping of Shanghai Zhongshan Medical College published an article in the "Chinese Journal of Internal Medicine", reporting that 22 cases of severe hepatitis had endotoxemia, and all of them had different degrees of upper gastrointestinal bleeding caused by fan-type vascular coagulation. Liver and kidney syndrome and endotoxemia seriously threaten the life safety of patients with severe liver disease, and pointed out that different degrees of endotoxemia occur regardless of acute, chronic hepatitis and liver cirrhosis. Since 1985, Professor Jin Xueyuan of Changchun Bethune University and Beijing China Rehabilitation Center has done a lot of research and experimental work with lactulose produced by our factory, with special emphasis on the research and clinical application of lactulose in the treatment of endotoxemia. Professor Jin Xueyuan treats patients with acute and chronic liver disease. Endotoxemia, oral lactulose, its plasma endotoxin can be reduced within 24 hours, and a large amount of lactulose can be given to remove normal portal endotoxin, it takes effect ten minutes after filling and can last for more than 4 hours. Jin Xueyuan observed in the experiment that oral administration of lactulose to large and small mice can prevent liver fibrosis caused by carbon tetrachloride, thereby preventing the transformation of chronic hepatitis to liver cirrhosis. From the above reports and experiments, combined with clinical tests in recent years, it has been proved that for patients with acute and chronic liver diseases and severe liver diseases, lactulose can be used as soon as they are admitted to the hospital, which can prevent the occurrence of syndrome and greatly shorten the course of liver disease. |
| pharmacological action | 1. lactulose is a synthetic non-absorbable disaccharide, which is not absorbed in the intestinal tract and can be decomposed into lactic acid and acetic acid by colon bacteria, so that the intestinal pH value drops below 6, which can block the absorption of ammonia, reduce the accumulation and absorption of endotoxin, and restore the blood ammonia of patients to normal, and turned from coma to sobriety. 2. Lactulose also has the osmotic activity of disaccharides, which can keep water and electrolytes in the intestinal cavity and produce hypertonic effect. Therefore, it is also an osmotic laxative. Because it has no intestinal irritation, it can also be used to treat chronic functional constipation. 3. It has anti-endotoxin effect. |
| overdose | if the dose is too high, abdominal pain or diarrhea may occur, just stop the drug. |
| pharmacology and toxicology | lactulose is converted into low molecular weight organic acids by digestive tract flora in colon, resulting in a decrease in pH value in intestinal tract and an increase in stool volume by retaining water. The above effects stimulate colon peristalsis, keep stool unobstructed, relieve constipation, and restore colon circadian rhythm. In the early stage of hepatic encephalopathy (PSE), hepatic coma and coma, the above effects promote the growth of intestinal acidophilic bacteria (such as Lactobacillus), inhibit proteolytic bacteria, and convert ammonia into ionic state; by reducing the contact pH value, exerting osmotic effect, and improving bacterial ammonia metabolism, thereby exerting cathartic effect. |
| preparation method | 1, chemical method alkali single catalysis: the system mainly uses sodium hydroxide, potassium hydroxide, potassium carbonate and tertiary amine as catalysts, and the conversion rate of lactulose is about 20%. This kind of alkaline reagent acts on lactose to isomerize lactose to produce lactulose, but at the same time it produces a considerable number of degradation products such as galactose, fructose, etc. The products are not only difficult to separate, but also often darker in color. The production of by-products and pigments not only reduces the yield of lactulose, but also brings difficulties to the further purification and crystallization of syrup. Acid-base synergistic catalysis: This system is by adding boric acid to the reaction system. Under alkaline conditions, boric acid can make lactulose form lactulose-borate complex, so that the balance of the reaction is in favor of lactulose. The direction of production moves. The formation of complexes and the movement of reaction equilibrium minimize the generation of degradation products. During the whole reaction process, only a small part of lactulose will be converted into by-products, and the conversion rate of lactulose is about 70%, up to 75%. After the conversion is completed, the pH of the reaction system is converted into acidity, and the complex will decompose to generate lactulose and borate, and then remove the borate to obtain pure lactulose. Because borate is a weak acid salt, the general anion exchange resin can hardly remove it below the safety standard. It is necessary to use ion exchange resin that specifically removes boric acid, which is more expensive. Acid-base co-catalytic preparation of lactulose reduces the generation of by-products, improves the yield of lactulose, and is conducive to the purification and refining of lactulose, which is also the main method of industrial production of lactulose. Sodium aluminate catalysis: The mechanism of action of this system is similar to that of boric acid. Sodium aluminate can undergo complexation reaction with lactulose generated by isomerization reaction, and the conversion rate of lactulose is about 60%; but in general, aluminate The generation ratio of by-products in the system is higher than that of the borate system, and the removal of aluminum ions is more difficult. In recent years, some scholars have used heterogeneous catalysts including zeolite, sepiolite, eggshell powder, oyster shell powder, etc. to prepare lactulose. It is found that the 20% conversion rate of lactulose can be obtained at 15g/L and 90 ℃. Using egg shell powder as catalyst, the conversion rate of lactulose was 18%-21% at 12g/L and 96 ℃ for 120min. Although zeolite, sepiolite, eggshell powder, oyster shell powder as catalyst lactulose conversion rate is not high, but they remain in a solid state, easy to remove by filtration, so non-uniform catalyst preparation of lactulose has strong development potential. the reaction process of producing lactulose by chemical isomerization 2, biological method enzymatic method is the main method of producing lactulose by biological method, and the enzyme used is mainly β-galactosidase. the principle is to hydrolyze lactose into galactose and glucose through the hydrolysis activity of β-galactosidase, galactose is transferred to the fructose receptor by the transglycosyl activity of β-galactosidase to produce lactulose. β-galactosidase, the full name is β-D-galactoside galactose hydrolase. In addition to its high activity of hydrolyzing lactose, it also has a high transglycoside activity that transfers galactose to fructose receptors. Early studies have shown that the active site on β-galactosidase has two functional groups: the sulfhydryl group of Cys and the imidazolyl group of His, which play an important role in the hydrolysis of lactose by β-galactosidase. It is speculated that the sulfur group can be used as a generalized acid to protonate the oxygen atom of galactoside, and the imidazolyl group can be used as a nucleophile to attack the nucleophilic center on the first carbon atom of the galactose molecule to form a carbon-hydrogen bond Covalent intermediate. After being cleaved, the sulfhydryl anion extracts 1 proton from the water molecule to form-OH attack C. β-galactosidase mainly comes from animals, plants and microorganisms. Such as lactic acid bacteria, Bacillus circulans, Escherichia coli, Streptococcus thermophilus, gas-producing intestinal bacteria, etc. in the bacteria; Aspergillus oryzae, Aspergillus niger, Aspergillus Ryukyu, Penicillium chrysogenum, Aspergillus charcoal, etc. in the yeast; Kluyveromyces lactis, Candida tropicalis, etc. in the yeast; Streptomyces azulae in the actinomycetes all produce β-galactosase. Due to the rapid growth of microorganisms and the biological characteristics of efficient metabolism, β-galactosidase derived only from microorganisms has industrial application value; commercial enzyme sources are generally considered to be the safest yeast, followed by Aspergillus niger. At present, due to the low activity of β-galactosidase transglycoside and the low conversion rate of lactulose, the application of biological method in the preparation of lactulose is limited. Some scholars at home and abroad have made some research on this, the purpose is to screen out microbial strains with high β-galactosidase transglycoside activity as much as possible. Using genetically modified heat-resistant lactase, lactose and fructose were used as substrates to produce 50 mg/ml lactulose at 80 ℃ for 6h. Enzymatic preparation of lactulose can overcome the chemical production of a large number of colored by-products difficult to separate, separation of these by-products of high cost and in the process of separation of lactulose degradation and other shortcomings, has a strong theoretical and practical significance, this is an important development direction of the preparation of lactulose in the future. |
| Pharmacokinetics | Lactulose is hardly absorbed after oral administration, reaches the colon as a prototype, and is then catabolized by intestinal flora. At a dose of 25-50g (40-75 ml), it can be completely metabolized; when this dose is exceeded, part of it is discharged as a prototype. |
| indications | this product is not digested and decomposed in stomach and small intestine, and is hardly absorbed in small intestine. There are many flora in the large intestine, and some of the beneficial bacteria (such as Lactobacillus bifidus) use lactulose as a nutrient. This product is decomposed into low molecular weight organic acids such as lactic acid and acetic acid in the colon, which reduces the intestinal pH to below 6, which is beneficial to the growth of beneficial bacteria and produces therapeutic effects. ① Treatment of constipation: The decomposition products of this product can stimulate the peristalsis of the large intestine, and at the same time make the large intestine retain more water, soften feces, and relieve constipation. ②Lowering blood ammonia: A larger dose of this product can promote the reproduction of sugar-decomposing bacteria, thereby inhibiting the growth of protein-decomposing bacteria, reducing the production of ammonia and other endotoxins, and also reducing the pH in the colon. In this state, most ammonia is converted into ammonium ions that are difficult to absorb, which reduces the absorption of ammonia and reduces blood ammonia. This product is not digested and decomposed in the stomach and small intestine, and has little absorption. It can only play a role in the large intestine, so the effect will not appear until 24 to 48 hours after taking this product. In the colon metabolism, less than 3% of the original drug is excreted in the urine, and a small amount of bile is excreted in the stool. It is used for the adjuvant treatment of hepatic coma and pre-coma state of hepatic encephalopathy, and also for the treatment of acute and chronic constipation and as an adjuvant drug for endotoxemia. |
| preparations and specifications | lactulose powder: 5 g/bag, 100 g/bag, 500 g/bag. Solution: 300ml/bottle, 15ml/bag (each ml contains 667mg of lactulose, galactose <110mg and lactose <60mg). Lactulose syrup: 60%. |
| usage and dosage | oral administration. Hepatic encephalopathy: used for hepatic coma and pre-coma state, the starting dose is 30 ~ 50ml each time, 3 times a day; the maintenance amount depends on personal circumstances, and the principle is to avoid diarrhea. Constipation: the dosage can be referred to the following table, such as 48 hours does not work, can consider to increase the dose; If diarrhea, should reduce the dose. It is best to take the medicine regularly, such as once a day, after breakfast. Or use the daily dose twice, take it once in the morning and once in the evening. oral scale for constipation |
| adverse reactions | rare serious adverse reactions. In the first few days of treatment, abdominal discomfort such as flatulence and cramps may occur; high-dose medication occasionally sees nausea and vomiting, and can also cause abnormal taste. An overdose can produce diarrhea, resulting in dehydration and massive loss of electrolytes. Hypernatremia has also been reported. |
| drug interaction | 1. combination with neomycin can improve the curative effect of treating liver disease. 2. It should not be taken with antacid to avoid reducing the curative effect. |
| precautions | gastric intestinal obstruction, lactic acidosis, uremia, diabetic acidosis, low galactose diet and inability to tolerate lactose are prohibited for patients with diabetes. large doses should be used with caution. It is not suitable for the first 3 months of pregnancy. Drug safety was not established for lactating women. |
| toxicity | non-toxic. |
| Main Reference Materials | [1] Application Status of Lactulose Oral Liquid [2] Editor-in-Chief Chen Jisheng. New clinical pharmacology. Beijing: China Traditional Chinese Medicine Press. 2013. [3] yimaitong medication reference [citation date 2017-05-31]. [4] Li Fenglin, Li Mingyang. Research Progress on Preparation Methods and Functions of Lactulose [J]. Beverage Industry, 2012,15(10):9-13. [5] Editor-in-Chief Ren Juanqing. Handbook of Practical Drugs. Jinan: Shandong Science and Technology Press. 2012.1279-12 |
| use | isomerized lactose is not absorbed by human body, but it can promote the proliferation of intestinal bifidobacteria and is beneficial to health. Our country stipulates that it can be used for milk powder, and the maximum usage amount is 15 g/kg; The maximum usage amount in biscuits is 2.0 g/kg; The maximum usage amount in beverages (liquid, solid) and fresh milk is 1.5 g/kg (all above are based on isomerized lactose dry matter). It has the effect of reducing blood ammonia and laxative, and is mainly used to treat ammonia-induced hepatic coma, hyperammonia and habitual constipation. Scientific research and experiments. Industrial use as an indirect nutritional supplement. According to China's GB 2760-86 regulations, can be added to fresh milk, beverages. This product is a proliferation factor of Bifidobacterium, a beneficial bacterium in the human intestine, which can help digest and absorb protein and lactose, and produce B vitamins. |
| Production method | is obtained by isomerization of lactose under the action of a base. The main component isomerized lactose content is more than 50%, the water content is 30%, and the rest are unreacted lactose and its decomposition products fructose, galactose and glucose. |
Last Update：2024-04-09 20:48:19
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Product Name: Lactulose Request for quotation
CAS: 4618-18-2
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Mobile: 0086 189 4982 3763
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CAS: 4618-18-2
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Product Name: Lactulose Visit Supplier Webpage Request for quotationCAS: 4618-18-2
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