MLS000544460
MLS000544460
CAS: 352336-36-8
Molecular Formula: C17H12FN3O2S
MLS000544460 - Names and Identifiers
| Name | MLS000544460 |
| Synonyms | MLS000544460 |
| CAS | 352336-36-8 |
MLS000544460 - Physico-chemical Properties
| Molecular Formula | C17H12FN3O2S |
| Molar Mass | 341.36 |
| Storage Condition | 2-8°C，干燥，密封 |
| In vitro study | MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg 2+ , it binds MLS000544460 with a higher affinity (K d =0.80 μM), indicating that this class of compounds does not require Mg 2+ for its interaction with the Eya2 ED. |
MLS000544460 - Reference Information
| biological activity | MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with Kd of 2.0 μM and IC50 of 4 μM. MLS000544460 inhibits Eya2 phosphatase-mediated cell migration and has anticancer activity. |
| target | Kd: 2.0 μM (Eya2 phosphatase) IC50: 4 μM (Eya2 phosphatase) |
| in vitro study | MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg 2 , it binds MLS000544460 with a higher affinity (K d = 0.80 μM), indicating that this class of compounds does not require Mg 2 for its interaction with the Eya2 ED. |
Last Update：2024-04-09 20:02:46
