Name | Methy methoxy acetate |
Synonyms | MOAM CBC 108569 METHYL METHOXYACETATE Methy methoxy acetate Methyl methoxy acetate METHYL 2-METHOXYACETATE methyl 2-methoxy acetate methylalpha-methoxyacetate methoxy-aceticacimethylester METHOXYACETIC ACID METHYL ESTER Methoxyacetic acid, methyl ether Acetic acid, methoxy-, methyl ester |
CAS | 6290-49-9 |
EINECS | 228-539-9 |
InChI | InChI=1/C4H8O3/c1-6-3-4(5)7-2/h3H2,1-2H3 |
Molecular Formula | C4H8O3 |
Molar Mass | 104.1 |
Density | 1.051g/mLat 25°C(lit.) |
Boling Point | 129-130°C(lit.) |
Flash Point | 96°F |
Water Solubility | soluble |
Solubility | Chloroform, Methanol |
Vapor Presure | 9.47mmHg at 25°C |
Appearance | Liquid |
Specific Gravity | 1.051 |
Color | Clear colorless to slightly brown |
BRN | 1742944 |
Storage Condition | Flammables area |
Refractive Index | n20/D 1.396(lit.) |
Physical and Chemical Properties | Colorless transparent liquid. |
Use | Used as medicine, pesticide, dye intermediates, medicine for the synthesis of vitamin B6 |
Risk Codes | 10 - Flammable |
Safety Description | S16 - Keep away from sources of ignition. S29 - Do not empty into drains. S33 - Take precautionary measures against static discharges. |
UN IDs | UN 3272 3/PG 3 |
WGK Germany | 2 |
RTECS | AI8910000 |
TSCA | Yes |
HS Code | 29189090 |
Hazard Class | 3 |
Packing Group | III |
colorless transparent liquid. The relative density was 1. 0511. Boiling point of 131 deg C (101. 7kPa). Refractive index 3964. Flash point 35 °c. Soluble in ethanol, ether, soluble in acetone, water-soluble.
The methoxylation reaction was carried out in methanol using methyl chloroacetate and sodium methoxide as raw materials. After the completion of the reaction, the salt is separated by filtration, and the solvent is removed by distillation, and then the finished product is obtained by distillation under reduced pressure.
pharmaceutical synthesis of intermediates, mainly used for the synthesis of sulfanilamide, vitamin B6, etc.
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
purpose | used as intermediate in medicine, pesticide and dye, intermediate in medicine for synthesis of vitamin B6 pharmaceutical synthesis, mainly used for the synthesis of week-effect sulfanilamide, vitamin B6, etc. |
production method | from methyl chloroacetate and sodium methoxide by methoxylation reaction. Sodium methoxide was added to the reaction pot, and methyl chloroacetate was added with stirring. The temperature was initially controlled at about 30 ° C., and the reaction was continued at about 70 ° C. Thereafter. Temperature is too high affect the quality of the finished color; Temperature is too low, the reaction rate is too slow. After completion of feeding, pH value shall be measured at the later stage of reaction. If pH value is less than 9, sodium methoxide shall be added for adjustment and heat preservation shall be continued until the end of reaction. The reaction product was distilled off methyl methoxyacetate in The desalting pan, while the sodium chloride formed by the reaction remained in the desalting pan. |