Molecular Formula | C17H28ClNO3 |
Molar Mass | 329.86 |
Melting Point | 181-183° |
Boling Point | 427°C at 760 mmHg |
Flash Point | 123.5°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 1.7E-07mmHg at 25°C |
Appearance | neat |
Color | White to Off-White |
Storage Condition | Inert atmosphere,Room Temperature |
Physical and Chemical Properties | Appearance: white or off-white crystalline powder |
Use | Local anesthetics |
In vitro study | Pramoxine is usually used in conjunction with Colloidal oatmeal, Hydrocortisone, Menthol, and Petrolatum. |
In vivo study | Pramoxine (1.7 mM) acted on the guinea pig ileum and decreased the response substance P to a lesser extent than the response to acetylcholine, histamine, and BaCl 2. Pramoxine acts on the ileum of guinea pigs and has an anesthetic inhibitory potency with a pKa of 6.4. Pramoxine deals with panting and shivering canines, both activated and inhibited, with specific skin temperature changes that are interpreted as peripheral mediation in the control of thermoregulatory mechanisms. |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | QD8750000 |
HS Code | 2934990002 |
Toxicity | LD50 i.v. in mice: 79.5 ±2.7 mg/kg (Schmidt); LD50 in mice (mg/kg): 300 i.p., 750 s.c. (Monash, Gibbs) |