MT-II

MT-II - Names and Identifiers

Name	MT-II
Synonyms	MT-II MelanotanII Acetate(MT-2) AC-NLE-CYCLO[(BETA-D)-HFRW-(EPSILON-K)]-NH2 AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2 AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2 AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2) AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT (AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) aMideMelanotan II, MTII, BreMelanotide aMide
CAS	121062-08-6
EINECS	1308068-626-2
InChIKey	JDKLPDJLXHXHNV-MFVUMRCOSA-N

MT-II - Physico-chemical Properties

Molecular Formula	C50H69N15O9
Molar Mass	1024.18
Density	1.43
Solubility	H2O: 5mg/mL, soluble
Appearance	white freeze-dried powder
Color	white
pKa	13.00±0.70(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
In vitro study	Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems such as the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system.
In vivo study	Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after i.v. melanotan (MT)-II (1 mg/kg), thereby exerting facilitator effect on erection. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model.

MT-II - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
WGK Germany	3
RTECS	OL4225000

MT-II - Reference

Reference

1. He Xinyu, Wang Bing, Zhou Yangyang et al. Enrichment and identification of metallothionein by functional magnetic nanoparticles combined with mass spectrometry [J]. Analytical chemistry 2018 046(007):1069-1076.
2.] xue Qixiang, Shen Xue, Tian Tian, Han Bing, Xie Ru Jia, He Yan, Yang Qin. Metallothionein reduces GRP78 and CHOP protein expression and alleviates hepatocyte apoptosis in rats with arsenic poisoning [J]. Basic & Clinical Medicine, 2015,35(06):739-743.
3. Gensheng Zhang, Xiaoxia Yue, Rui Wang, et al. Determination of metallothionein in whole egg powder [J]. Science and Technology of food industry, 2018, 039(019):214-219.
4. Li, Shan, et al. "Determination of metallothionein isoforms in fish cadmium saturation combined with anion exchange HPLC-ICP-MS." Chromatographia 81.6 (2018): 881-889.https://doi.org/10.1007/s10337-018-3523-3
5. [IF=2.044] Li Shan et al."Determination of Metallothionein Isoforms in Fish by Cadmium Saturation Combined with Anion Exchange HPLC-ICP-MS."Chromatographia. 2018 Jun;81(6):881-889

MT-II - Reference Information

Use	Melanotan II is a laboratory-made chemical that is similar to a hormone in the human body. Melanotan II has been shown to have melanogenesis (tanning) and aphrodisiac effects in humans.
biological activity	Melanotan (MT)-II is a synthetic melanocortin receptor agonist. It is an injectable polypeptide hormone that promotes tanning.

Last Update：2024-04-09 20:52:54