Name | MX69 |
Synonyms | MX69 MX-69 CS-2402 MX69 (MX 69 Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]- |
CAS | 1005264-47-0 |
Molecular Formula | C27H26N2O4S |
Molar Mass | 474.57 |
Solubility | DMSO: ≥ 30 mg/mL |
Storage Condition | -20℃ |
In vitro study | MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro. |
In vivo study | MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.107 ml | 10.536 ml | 21.072 ml |
5 mM | 0.421 ml | 2.107 ml | 4.214 ml |
10 mM | 0.211 ml | 1.054 ml | 2.107 ml |
5 mM | 0.042 ml | 0.211 ml | 0.421 ml |
biological activity | MX69 is an MDM2/XIAP inhibitor, commonly used in anti-cancer research. |
in vitro study | MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animalmodels. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro. |
in vivo study | MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo. |