Mangosteen
Mangostine
CAS: 6147-11-1
Molecular Formula: C24H26O6
Mangosteen - Names and Identifiers
| Name | Mangostine |
| Synonyms | NSC 27593 Mangostin NSC 30552 Mangosteen NSC 139154 Mangostine alpha-Mangostin Alpha-Mangostinα-Mangostin α-Mangostin, froM Garcinia Mangostana 1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)- (8CI) 9H-Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)- (9CI) |
| CAS | 6147-11-1 |
| EINECS | 683-120-1 |
| InChI | InChI=1/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3 |
| InChIKey | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
Mangosteen - Physico-chemical Properties
| Molecular Formula | C24H26O6 |
| Molar Mass | 410.46 |
| Density | 1.265±0.06 g/cm3(Predicted) |
| Melting Point | 180-182°C |
| Boling Point | 640.1±55.0 °C(Predicted) |
| Flash Point | 220.3°C |
| Solubility | Insoluble in water, easily soluble in n-hexane, chloroform, ethyl acetate and other low-polar solvents. |
| Vapor Presure | 5.59E-17mmHg at 25°C |
| Appearance | Yellow powder |
| Color | faint yellow to yellow |
| Maximum wavelength(λmax) | ['346nm(MeOH)(lit.)'] |
| pKa | 7.22±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.624 |
| MDL | MFCD00135200 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from garcinaceae (Guttiferae) mangosteen shell, mangosteen, mangosteen. |
| In vitro study | alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H 2 O 2 -induced apoptosis of RPE cells. 200 μM H 2 O 2 -induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin). |
| In vivo study | alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone. |
Mangosteen - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 1 |
| RTECS | ZD6122420 |
| HS Code | 29329990 |
Mangosteen - Reference
| Reference Show more | 1. [IF=2.408] Amit Jaisi et al."Investigation of HIV-1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents."Chemistry & Biodiversity. 2021 Oct 27 |
Mangosteen - Nature
Open Data Verified Data
The main functional ingredient is mogroside, and the difference between the various Mogrosides lies in the difference of sugar ligands. The extract of momordica grosvenori is light yellow powder to Brown extract. Taste very sweet, the sweetness of more than 240 times the sweetness of sucrose, sweet sugar is close to, there are slightly similar to the aftertaste of licorice, high purity mogroside melting point of 197~201 ℃. Soluble in water and ethanol.
Last Update：2024-01-02 23:10:35
Mangosteen - Preparation Method
Open Data Verified Data
with momordica grosvenori fruit as raw material for extraction.
Last Update：2022-01-01 11:15:31
Mangosteen - Use
Open Data Verified Data
can be used as a sweetener.
Last Update：2022-01-01 11:15:32
Mangosteen - Reference Information
| Overview | α-inverted twig is an Oxo anthracene compound extracted from the plant bamboo. In addition, the α-inverted twist element is derived from the active ingredients of natural mountain bamboo, which has the characteristics of safety, non-toxicity and a long history of eating, it provides a theoretical and applied basis for the further study of α-inverted spersin as a drug. |
| biological activity | alpha-Mangostin (α-mangostin) is a dietary xanthone with a wide range of biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of the IDH1 mutant (IDH1-R132H) with a Ki value of 2.85 μm. |
| Target | IC50: 2.85 μm (IDH1-R132H) |
| Use | α-Orexin is effective in the treatment of Diarrhea, malaria, anti-inflammatory, anti-ulcer and anti-leukemic and septic effects. for content determination/identification/pharmacological experiments and other pharmacological effects: with antioxidant, anti-inflammatory, antibacterial, anticancer and other pharmacological activities |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:32:07
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Product Name: Mangostin Visit Supplier Webpage Request for quotationCAS: 6147-11-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: α-mangostin Visit Supplier Webpage Request for quotationCAS: 6147-11-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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