Marimastat
Marimastat
CAS: 154039-60-8
Molecular Formula: C15H29N3O5
Marimastat - Names and Identifiers
Marimastat - Physico-chemical Properties
| Molecular Formula | C15H29N3O5 |
| Molar Mass | 331.41 |
| Density | 1.140±0.06 g/cm3(Predicted) |
| Melting Point | 148℃ |
| Solubility | DMSO: ≥20mg/mL |
| Appearance | White solid |
| pKa | 9.44±0.40(Predicted) |
| Storage Condition | -20°C |
| In vitro study | In U251, U87, GBM39 and GBM43 tumor cells, Marimastat(100 nM) can significantly inhibit the expression of mmp14. Marimastat can specifically inhibit the growth of glioma cells and has no effect on normal human astrocytes (NHA). Early Marimastat can down-regulate the expression of Notch target genes, such as Hes1 and hes5. |
| In vivo study | In the orthotopic squamous cell carcinoma transplantation model, marimastat(150 mg/kg/day, oral administration) can significantly inhibit the cervical lymph node metastasis and MMP-2 activation by osmotic pump, compared with the control group, the survival time was significantly prolonged. Marimastat reduces polycystic MMP hyperactivity in human and rat bile ducts, blocking PCK cystic dilation of the bile duct. In eight-week-old PCK rats, chronic treatment with marimastat inhibited hepatic cyst formation and fibrosis. |
Marimastat - Risk and Safety
| WGK Germany | 3 |
| RTECS | EJ6665000 |
| HS Code | 29241990 |
Marimastat - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.017 ml | 15.087 ml | 30.174 ml |
| 5 mM | 0.603 ml | 3.017 ml | 6.035 ml |
| 10 mM | 0.302 ml | 1.509 ml | 3.017 ml |
| 5 mM | 0.06 ml | 0.302 ml | 0.603 ml |
Last Update：2024-01-02 23:10:35
Marimastat - Reference Information
| biological activity | Marimastat (BB-2516, TA2516) is a broad-spectrum matrix metalloprotease (MMP) inhibitor with IC50 of 3 nM,5 nM,6 nM,9 nM and 13 nM for MMP-9,MMP-1,MMP-2,MMP-14 and MMP-7, respectively. Phase 3. | |||||
| target | TargetValue MMP-9 3 nM MMP-1 5 nM MMP-2 6 nM MMP-14 9 nM MMP-7 16 nM | |||||
| Target | Value | |||||
| MMP-9 (cell-free assay) | 3 nM | |||||
| MMP-1 (cell-free assay) | 5 nM | |||||
| MMP-2 (cell-free assay) | 6 nM | |||||
| MMP-14 (cell-free assay) | 9 nM | |||||
| MMP-7 (cell-free assay) | 16 nM | |||||
| in vitro study | in U251, U87, GBM39 and GBM43 tumor cells, Marimastat(100 nM) can significantly inhibit the expression of MMP14. Marimastat can specifically inhibit the growth of glioma cells and has no effect on normal human astrocytes (NHA). Early Marimastat can down-regulate the expression of Notch target genes, such as Hes1 and HES5. | |||||
| in vivo study | in situ squamous cell carcinoma transplantation model, marimastat(150 mg/kg/day, oral administration) can significantly inhibit cervical lymph node metastasis and MMP-2 activation by osmotic pump administration, and the survival time is significantly prolonged compared with the control group. Marimastat can reduce polycystic MMP hyperactivity in human and rat bile ducts and block cystic dilatation of PCK bile ducts. marimastat chronic treatment inhibited hepatic cyst formation and fibrosis in eight-week-old PCK rats. |
Last Update：2024-04-09 20:52:54
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CAS: 154039-60-8
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Product Name: Marimastat Visit Supplier Webpage Request for quotation
CAS: 154039-60-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 154039-60-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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