Methoxyhydroxyethane
2-Methoxyethanol
CAS: 109-86-4
Molecular Formula: C3H8O2
Methoxyhydroxyethane - Names and Identifiers
| Name | 2-Methoxyethanol |
| Synonyms | EM 2ME EGM MECS EGME Ektasolve Dowanol Em Jeffersol Em METHYL OXITOL METHOXYETHANOL Methyl Ethoxol Glycol Ether Em 1-methoxyethanol 2-Methoxyethanol METHYLCELLUSOLVE 2-METHOXYETHANOL Glycomethyl Ether Methyl Cellosolve METHYL CELLOSOLVE Methoxyethanol, 2- Methyl 'Cellosolve' Methoxyhydroxyethane METHOXYHYDROXYETHANE METHYL CELLOSOLVE(R) ACIDIFIED CLEAR WATER Glycol Monomethyl Ether Ethylene Glycol Methyl Ether Ethylene Glycol Monomethyl Ether Ethylene Glycol Mono Methyl Ether |
| CAS | 109-86-4 |
| EINECS | 231-791-2 |
| InChI | InChI=1/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3 |
| InChIKey | XNWFRZJHXBZDAG-UHFFFAOYSA-N |
Methoxyhydroxyethane - Physico-chemical Properties
| Molecular Formula | C3H8O2 |
| Molar Mass | 76.09 |
| Density | 0.965 g/mL at 25 °C(lit.) |
| Melting Point | -85 °C |
| Boling Point | 124-125°C(lit.) |
| Flash Point | 115°F |
| Water Solubility | SOLUBLE |
| Solubility | Very soluble in acetone, dimethylsulfoxide, and 95% ethanol (quoted, Keith and Walters, 1992).Miscible with N,N-dimethylformamide, ether, and glycerol (Windholz et al., 1983). |
| Vapor Presure | 6.17 mm Hg ( 20 °C) |
| Vapor Density | 2.62 (vs air) |
| Appearance | Liquid |
| Color | green cap |
| Odor | Mild ethereal. |
| Exposure Limit | TLV-TWA skin 5 ppm (15.5 mg/m3)(ACGIH), 25 ppm (77.5 mg/m3) (OSHA). |
| Maximum wavelength(λmax) | ['λ: 213 nm Amax: 1.00', , 'λ: 240 nm Amax: 0.20', , 'λ: 260 nm Amax: 0.05', , 'λ: 30 |
| Merck | 14,6038 |
| BRN | 1731074 |
| pKa | 15.7(at 25℃) |
| Storage Condition | Store at +5°C to +30°C. |
| Stability | Stable, but contact with air may lead to the formation of explosive peroxides. A peroxide test should be carried out before this material is used if it has been exposed to air for some time, especiall |
| Explosive Limit | 2.5-20%(V) |
| Refractive Index | n20/D 1.402(lit.) |
| Physical and Chemical Properties | Colorless transparent liquid with pleasant odor. melting point -85.1 ℃ boiling point 125 ℃ relative density 0.9647 refractive index 1.4024 flash point 46.1 ℃ solubility in water, ethanol, diethyl ether, glycerol, acetone, N,N-dimethylformamide miscible. |
| Use | Used as coating solvent, penetrant, levelling agent and organic synthesis intermediate, also used as an additive for jet fuel |
Methoxyhydroxyethane - Risk and Safety
| Risk Codes | R60 - May impair fertility R61 - May cause harm to the unborn child R10 - Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R35 - Causes severe burns R34 - Causes burns R36/38 - Irritating to eyes and skin. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S23 - Do not breathe vapour. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 1188 3/PG 3 |
| WGK Germany | 3 |
| RTECS | ZC0110000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29332990 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth); LC50 (7 hr in air) in mice: 4.6 mg/l (Werner) |
Methoxyhydroxyethane - Upstream Downstream Industry
| Raw Materials | 1-Butanol Ethylene Oxide Methyl alcohol Ethyl Alcohol |
| Downstream Products | 1,2-Dimethoxyethane nimodipine |
Methoxyhydroxyethane - Nature
Open Data Verified Data
colorless transparent liquid, with pleasant odor, toxic. The relative density was 0.9647. Boiling Point (102. 391kPa) 125 °c, melting point -85.1 °c. Flash point 46.1 °c. Refractive index 4024. Spontaneous ignition point 288.3. Miscible with water, ethanol, ether, glycerol, acetone, N,N-dimethylformamide.
Last Update：2024-01-02 23:10:35
Methoxyhydroxyethane - Preparation Method
Open Data Verified Data
first put methanol into boron trifluoride-diethyl ether complex, slowly pass ethylene oxide under stirring to generate ethylene glycol monomethyl ether, and neutralize with alkali, distilled off excess methanol at atmospheric pressure and recovered, the desired product was distilled off under reduced pressure.
Last Update：2022-01-01 10:15:55
Methoxyhydroxyethane - Use
Open Data Verified Data
solvents for various oils and fats, nitrocellulose, alcohol-soluble dyes and synthetic resins, reagents for the determination of iron, sulfate and carbon disulfide, fast-drying solvents for enamel and varnish, diluents for coating, penetrants and levelling agents in the dye industry. It is also used in the formulation of sealants. As an intermediate in the production of organic compounds, ethylene glycol monomethyl ether is mainly used in the synthesis of acetate and ethylene glycol dimethyl ether. It is also a raw material for the production of BIS (2-methoxyethyl) phthalate plasticizers. In addition, it can also be used as an antifreeze additive for military air jet dyes.
Last Update：2022-01-01 10:15:56
Methoxyhydroxyethane - Safety
Open Data Verified Data
toxic, can cause anemia (giant red cell type), the emergence of new granular white blood cells and cause central nervous system disorders. Rat oral ld502460 mg/kg, mouse LC1500 x 10-6. The maximum allowable concentration in the air of the workplace is 80mg/m3. The operator should wear protective gear.
Packaged in glass or iron barrels of 4. 5L, 22. 5L or 240L per barrel. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:15:56
Methoxyhydroxyethane - Reference Information
| pH range of acid-base indicator discoloration | 5- 7 at 25°C |
| relative polarity | 1 |
| Henry's Law Constant | (x 10-2 atm?m3/mol):4.41, 3.63, 11.6, 3.09, and 3.813 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth etal., 1988) |
| LogP | -0.77 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | ethylene glycol monomethyl ether (abbreviated as MOE), also known as ethylene glycol methyl ether, is a colorless transparent liquid, water, alcohol, acetic acid, acetone and DMF were miscible. As an important solvent, MOE is widely used as a solvent for various oils and fats, cellulose acetate, cellulose nitrate, alcohol soluble dyes and synthetic resins. |
| Application | fast-drying solvents for enamel and varnish, coating diluents, penetrants and levelling agents in the dye industry, it is also used for printing ink and the preparation of sealant, the manufacture of plasticizer. In recent years, MOE is more and more used in the pharmaceutical industry, aviation jet fuel anti-icing agent, brake oil diluent, etc., and the dosage is increasing year by year. It is derived from the reaction of ethylene oxide with methanol. |
| preparation | CN201110440309.9 provides a preparation method of ethylene glycol monomethyl ether, a chromatographic grade organic solvent with simple process, stable quality and high product purity. The steps are as follows: (1) the raw material ethylene glycol monomethyl ether is adsorbed through an adsorption column equipped with an adsorbent at a flow rate of 30mL-100mL/min; (2) step (1) the effluent of ethylene glycol monomethyl ether after adsorption is added with 2,4 dinitrophenylhydrazine with a weight ratio of 0.1% and stirred for 1H ~ 2H, then passed through a drying column equipped with a desiccant, and the water content after drying is controlled at less than or equal to 0.05%; (3) the ethylene glycol monomethyl ether dried in step (2) is put into a rectification kettle for rectification, and calcium hydride is added in the kettle, and the amount is 0.1-0.3% of the weight ratio of ethylene glycol monomethyl ether, the bottom temperature of the rectification kettle is 180~300 ℃, the liquid temperature in the kettle is 130~150 ℃, the top temperature is 124 ℃, and the reflux ratio is controlled to 10: 2~8, the reflux time is 2 to 4 hours, and the filtrate is a chromatographic grade ethylene glycol monomethyl ether by filtering through a micropore filter after rectification. |
| Use | used as solvent, penetrant, levelling agent and organic synthesis intermediates, also used as an additive for jet fuel 2-methoxyethanol, also known as ethylene glycol monoether, is an intermediate of the herbicide ethersulfuron, and is also a solvent for various oils and fats nitrocellulose and synthetic resins. The product is used as a solvent for various oils and fats, lignin, nitrocellulose, cellulose acetate, alcohol soluble dyes and synthetic resins; A reagent for the determination of iron, sulfate and carbon disulfide, a diluent for coating, and used in the packaging and sealing of cellophane, quick-drying varnish and enamel. It can also be used as a penetrating agent and leveling agent in the dye industry, or as a plasticizer and brightener. As an intermediate in the production of organic compounds, ethylene glycol monomethyl ether is mainly used in the synthesis of acetate and ethylene glycol dimethyl ether. It is also a raw material for the production of BIS (2-methoxyethyl) phthalate plasticizers. Ethylene glycol monomethyl ether with glycerol and mixtures (Ether: glycerol = 98:2) is a military jet fuel additive, anti-icing and anti-bacterial corrosion. When ethylene glycol monomethyl ether is used as the anti-slurry agent for jet fuel, the general addition amount is 0.15%± 0.05%, it has good hydrophilicity, and hydrogen bonds are formed between the molecules of the hydroxyl group and the water in the oil in the fuel, in addition, the freezing point of itself is very low, thus reducing the freezing point of water in the oil, so that the water can be precipitated into Frost, ethylene glycol monomethyl ether is also an anti-microbial additive. used as a reagent and solvent for the determination of iron, sulfate and carbon disulfide analysis reagent, used for the determination of trace water in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine, carbon tetrachloride and so on. determination of iron; Sulfate and carbon disulfide reagents, used as a variety of oils and fats; Lignin; Nitrocellulose; Cellulose acetate; Alcohol-soluble dyes and synthetic resin solvents |
| production method | is obtained by reacting ethylene oxide with methanol. Methanol was added to the boron trifluoride diethyl ether complex, and ethylene oxide was introduced at 25-30 °c under stirring. After passing, the temperature was automatically raised to 38-45 °c, and the resulting reaction solution was neutralized to pH = 8-9 with potassium hydrogen cyanide-methanol solution. Methanol was recovered, distilled, and the crude product was obtained by collecting the fraction before 130 °c. After fractionation, the 123-125 °c fraction was collected as the finished product. In industrial production, the reaction of ethylene oxide and anhydrous methanol at high temperature and high pressure, without catalyst, can obtain high yield of products. The preparation method is to add methanol to the boron trifluoride ether complex, and add ethylene oxide at 25~300 ℃ under stirring. After passing, the temperature will automatically rise to 38~45 ℃, the resulting reaction solution was neutralized with potassium hydroxide methanol solution to pH = 8-9, methanol was recovered, distilled, and then subjected to fractional distillation to obtain the product. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2370 mg/kg; Oral-mouse LD50: 2560 mg/kg |
| stimulation data | Skin-rabbits 463 mg/24 h mild; eye-rabbit 500 mg/24 h mild |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant; combustion-induced smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | TWA 16 mg/m3; Tel 120 mg/m3 |
| spontaneous combustion temperature | 548 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 200 ppm |
Last Update：2024-05-07 11:42:14
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Raw Materials for Methoxyhydroxyethane
Downstream Products for Methoxyhydroxyethane