Name | Cresol |
Synonyms | Cresol cresoli Cresols bacillol CRESOL,CP artoluenol Methylphenol Crude phenols MIXED CRESOLS Cresylic acid coaltarphenols 2-methylphenol Crude carbolic acid METHYLPHENOL TRICRESOL Cresols (all isomers). Cresol (mixed isomers) m-cresol,o-cresol,p-cresol Cresol(mixture of isomers) Cresol, mixture of isomers Gemisch aus o-, m- und p-Kresol CresolMixedIsomers(CresylicAcid) CRESOL MIXTURE OF ISOMERS, CRUDE |
CAS | 1319-77-3 |
EINECS | 215-293-2 |
InChI | InChI=1/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3 |
InChIKey | QTWJRLJHJPIABL-UHFFFAOYSA-N |
Molecular Formula | C7H8O |
Molar Mass | 108.14 |
Density | 1.04 |
Melting Point | -1--2°C |
Boling Point | 88-94°C |
Flash Point | 82°C |
Water Solubility | 1.932 g/100 mL |
Vapor Presure | 0.379mmHg at 25°C |
Appearance | clear liquid |
Color | Colorless to Almost colorless |
Odor | Sweet, tarry. |
Exposure Limit | TLV-TWA (skin) for all isomers, 5 ppm(~22 mg/m3 ) (ACGIH, MSHA, and OSHA),10-hour TWA 2.3 ppm (~10 mg/m3 )(NIOSH), IDLH 250 ppm (NIOSH). |
Merck | 14,2579 |
Storage Condition | Store at R.T. |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Refractive Index | 1.5410 to 1.5440 |
Physical and Chemical Properties | Density 1.04 melting point -1-2°C boiling point 88-94°C flash point 82°C water solubility 1.932g/100 mL |
Use | Used as a raw material for synthetic resins, insulating paints, antioxidants, also used as disinfectants and solvents |
Hazard Symbols | T - Toxic |
Risk Codes | R20 - Harmful by inhalation R24/25 - R34 - Causes burns R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68 - Possible risk of irreversible effects |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S24/25 - Avoid contact with skin and eyes. |
UN IDs | UN 2076 6.1/PG 2 |
WGK Germany | 1 |
RTECS | GO5950000 |
FLUKA BRAND F CODES | 8-23 |
HS Code | 29071219 |
Hazard Class | 6.1(a) |
Packing Group | II |
Raw Materials | Cresol Sulfuric acid Sodium hydroxide |
Downstream Products | m-Anisidine |
A mixture of ortho-, meta-and para-cresol isomers. Colorless, pale yellow or pink liquid. There is phenol odor. Flammable. Soluble in ethanol, ethylene glycol and dilute alkali. The relative density ranged from 1. 030 to 1. 047. Melting Point 11~35 °c. Boiling point 191~203 deg C.
This product is a mixture of various cresol isomers obtained by fractionation in coal tar.
The relative density of this product (General 0601) is 1.030~1.050. Distillation range take this product, according to the determination method of distillation range (General 0611), the amount of 190~205 C distillation should be not less than 85%(ml/ml).
used in phenolic resin, electrical insulation paint, tricresyl phosphate, dyes, disinfectants, surfactants, flotation agents, lubricating oil additives, enamel solvents. Used as a preservative, cold plastic plasticizer, cracking dispersant and solvent in the production process of Sebacic acid.
take 1.0ml of this product, Add 60ml of water to dissolve it, if it is turbid, take 57ml of water, add L. 5ml of sulfuric acid titration solution (0.01mol/L) and 2ml of barium chloride test solution, shake, place for 5 minutes] comparison, not more concentrated.
take this product, put it on a water bath, and dry it at 105°C to constant weight. The residue should not exceed 0.1%.
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 0.8%.
Disinfection antiseptic.
light shielding, sealed storage.
This product contains Cresol (C7H80) should be labeled the amount of 85.0% ~ 110.0%.
cresol 520g(500ml)
Vegetable oil 173g
Appropriate amount of sodium hydroxide (about 27g)
Appropriate amount of water
Made up to 1000ml
take sodium hydroxide, add 100ml of water to dissolve, let it cool, add human vegetable oil with constant stirring, emulsify evenly, place it for 30 minutes, and slowly heat it (indirect steam or water bath), when the color of the soap body is deepened, it is transparent and then stirred; And can be proportionally prepared into small samples, check the unsaponifiable matter, if qualified, it is considered that the Saponification is complete; while hot, add cresol and stir until the soap block is completely dissolved, let it cool, and then add appropriate amount of water to make the total amount to 1000ml. The vegetable oil in the prescription can be replaced by low and medium carbon fatty acids.
with cresol.
light shielding, sealed storage.
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | cresol can be used in the synthesis of materials auxiliaries and dye intermediates. used as raw material of synthetic resin, insulating paint, antioxidant, also used as disinfectant and solvent used in phenolic resin, electrical insulating paint, tricresyl phosphate, dye, surfactant, flotation agent, lubricant additive, enamel solvents, preservatives, cold-proof plastic plasticizers, cracking dispersants and sebacic acid in the production process of solvents. The bactericidal power of cresol is 4 times that of phenol, and soap water is usually added to the mixed cresol to emulsify, that is, to form the disinfectant LyX water. The separation of O-, m-and p-cresol from mixed cresol, including the mixture of m-cresol, has a wide range of applications in organic synthesis. solvent, Disinfection preservative, bactericidal for 4 times of carbolic acid. Synthetic resin. |
identification | 1. Take the saturated aqueous solution of this product and add ferric chloride solution, which is the purple blue color that is easy to disappear. 2. Take the saturated solution of this product and add bromine test solution to precipitate light yellow flocculent precipitate. |
production method | There are many methods for synthesizing cresol, and the content of isomers in the products obtained by each method is also different. The process of toluene sulfonation is similar to that of benzene sulfonation to phenol. Toluene was first sulfonated to give toluene sulfonic acid, and the molten sulfonated product was then treated with sodium hydroxide to give the sodium salt of cresol. The sodium salt is mixed with water and acidified by the addition of sulfur dioxide or by the addition of sulfuric acid to give cresol. After the moisture of the crude cresol was distilled off under a low degree of vacuum, a fraction of 150-200 ° C. Was collected under a vacuum of (80-93.3kPa) to obtain mixed cresol. Among them, the ratio of the Ortho, Inter and the three isomers varies with the reaction conditions. In general, the para position is the most, the meta position is less, and the ortho position is less. This method consumes 30% of toluene and 5000 of liquid alkali per ton of mixed cresol. 2. Methyl isopropyl benzene oxidation method this is the United States of the United States hergris explosives company to use the method. Toluene was alkylated with propylene to give a mixture of methyl isopropylbenzene with a ratio of 2.5 to 3:1 of Inter, para and steric isomers, in which the ortho isomer was small. Methyl cumene is then oxidized to methyl cumene peroxide at 25-35 °c by introduction of an oxygen-containing gas, which is then treated with sulfuric acid to obtain cresol rich in meta-isomer and para-isomer, and acetone is co-produced. This method is similar to the process of producing phenol and acetone by cumene method. The method of coal tar fractionation is obtained by fractionation of crude phenol, which is a by-product of high temperature coking. |
category | corrosive article |
toxicity grade | poisoning |
Acute toxicity | oral-rat LD50: 1454 mg/kg; Oral-mouse LD50: 760 mg/kg |
explosive hazard characteristics | explosive when mixed with air; Corrosive skin, cornea |
flammability hazard characteristics | flammable; Hot gas |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant. |
fire extinguishing agent | dry powder, carbon dioxide, foam, water mist |
Occupational Standard | TLV-TWA 5 PPM (22 mg/m3) |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |