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Minoxidil

minoxidil

CAS: 38304-91-5

Molecular Formula: C9H15N5O

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Minoxidil - Names and Identifiers

Name minoxidil
Synonyms alostil
lonolox
alopexil
minoxidil
6-piperidino-2,4-diaminopyrimidine3-oxide
2,4-Diamino-6-piperidino-pyrimidine-3-oxide
2,4-diamino-6-piperidinopyrimidine3-n-oxide
4-pyrimidinediamine,6-(1-piperidinyl)-3-oxide
6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide
6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate
(2E)-6-amino-2-imino-4-(piperidin-1-yl)pyrimidin-1(2H)-ol
6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
CAS 38304-91-5
EINECS 253-874-2
InChI InChI=1/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12)
InChIKey ZFMITUMMTDLWHR-UHFFFAOYSA-N

Minoxidil - Physico-chemical Properties

Molecular FormulaC9H15N5O
Molar Mass209.25
Density1.1651 (rough estimate)
Melting Point272-274 °C (dec.) (lit.)
Boling Point348.61°C (rough estimate)
Flash Point283.364°C
Water SolubilitySoluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Solubility Slightly soluble in ethanol and chloroform, almost insoluble in water
Vapor Presure0mmHg at 25°C
AppearanceCrystalline powder
ColorWhite
Merck14,6203
pKa4.61(at 25℃)
Storage Condition2-8°C
StabilityStable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Refractive Index1.7610 (estimate)
MDLMFCD00063409
Physical and Chemical Properties

Appearance: White Crystal

Melting Point: 258-262 ℃

UseAntihypertensive drugs for the treatment of refractory, primary, or renal hypertension

Minoxidil - Risk and Safety

Risk CodesR22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S22 - Do not breathe dust.
WGK Germany3
RTECSUV8200000
HS Code29335990
ToxicityLD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra)

Minoxidil - Reference

Reference
Show more
1. Feng Jiaoji Hongyu Zhang Chengcheng et al. Determination of minoxidil in minoxidil microemulsion by HPLC [J]. China pharmacist 2018 21(09):185-188.
2. Xu, Kexin, et al. "Glibenclamide Targets Sulfonylurea Receptor 1 to Inhibit p70S6K Activity and Upregulate KLF4 Expression to Suppress Non-Small Cell." Molecular cancer therapeutics 18.11 (2019): 2085-2096.

Minoxidil - Standard

Authoritative Data Verified Data

This product is 6-(1-piperidinyl)-2, 4-pyrimidine diamine, 3-oxide. The content of C9H15N50 shall not be less than 99.0% calculated as dry product.

Last Update：2024-01-02 23:10:35

Minoxidil - Trait

Authoritative Data Verified Data
  • This product is white or off-white crystalline powder.
  • This product is slightly soluble in ethanol, slightly soluble in chloroform or water, and slightly soluble in acetone; Dissolved in glacial acetic acid.
Last Update：2022-01-01 11:54:15

Minoxidil - Differential diagnosis

Authoritative Data Verified Data
  1. take this product, dissolve and dilute with ethanol to make a solution containing about 6ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is an absorption maximum at a wavelength of 231nm.
  2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 608).
Last Update：2022-01-01 11:54:16

Minoxidil - Exam

Authoritative Data Verified Data

chlorine-containing compounds

take about 20mg of this product, precision weighing, according to the oxygen flask combustion method (General 0703) for organic damage, with 0.lmol/L sodium hydroxide solution (10ml) was used as absorption liquid. After the combustion was completed, it was shaken strongly for several minutes, and the bottle stopper and platinum wire were rinsed with a small amount of water, move the absorption liquid into a 50ml Nessler's Cuvette, and check with the control liquid according to the chloride inspection method (General rule 0801) (operate in the same manner as the test sample, but do not contain the test sample in the filter paper during combustion, and add standard sodium chloride solution 4.0ml) comparison, not more concentrated (0.2%).

Related substances

take an appropriate amount of this product, accurately weigh, add mobile phase to dissolve and dilute to make a solution containing about 0.25mg per lml, as a test solution; Take an appropriate amount of precision, A solution containing about 2.5ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. Test according to high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane as filler; Methanol-water-glacial acetic acid (70:30:1)(3.0g of sodium Dioctyl Sulfosuccinate per 3.0 ML, and adjust the pH value to with perchloric acid) mobile phase; The detection wavelength was 240nm. Take appropriate amount of this product and medroxyprogesterone acetate, add mobile phase to dissolve and dilute to make a mixed solution containing about 0.25mg in each lml, take 10ul, inject human liquid chromatograph, record chromatogram, the number of theoretical plates is not less than 2000 calculated by minoxidil peak, and the separation degree between minoxidil peak and medroxyprogesterone acetate peak should be greater than 2.0. Take 10 u1 of the test solution and the control solution respectively, inject the human liquid chromatograph, record the chromatogram to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule: 0841). The residual residue shall not exceed 0.15%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).

Last Update：2022-01-01 11:54:17

Minoxidil - Content determination

Authoritative Data Verified Data

take this product about 0.15g, precision weighing, add glacial acetic acid 50ml, micro temperature to dissolve, according to the potential titration method (General 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 20.93mg of C9H15N50.

Last Update：2022-01-01 11:54:17

Minoxidil - Category

Authoritative Data Verified Data

antihypertensive drugs.

Last Update：2022-01-01 11:54:17

Minoxidil - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:54:18

Minoxidil - Minoxidil tablets

Authoritative Data Verified Data

This product contains minoxidil (C9H15N50) should be 90.0% to 110.0% of the label.

trait

This product is white tablet.

identification

  1. take an appropriate amount of fine powder of this product (about 5mg equivalent to minoxidil), add 3ml of ethanol, shake, filter, evaporate the filtrate, take the residue, add 1ml of acetic anhydride and 10mg of citric acid, after heating in a water bath for 2 minutes, the color gradually turned red.
  2. the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of NM and Nm.

examination

  • Content uniformity take 1 tablet of this product, put it in a 50ml measuring flask, add an appropriate amount of hydrochloric acid solution (9-1000), shake to dissolve minoxidil, and dilute to the scale with hydrochloric acid solution (9-1000), shake well, filter, take 2ml of filtrate accurately, put it in a 25ml measuring flask, dilute to the scale with hydrochloric acid solution (9-1000), shake well, and determine the content according to the method under the content determination item, should comply with the provisions (General 0941)o
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 20 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to minoxidil 20mg), put it in a 100ml measuring flask, add hydrochloric acid solution (9-1000) about 60ml, shake to dissolve minoxidil, dilute to the scale with hydrochloric acid solution (9-1000), shake well, filter, take 2ml continuous filtrate and place it in another 100ml measuring flask, dilute to scale with hydrochloric acid solution (9-1000), shake well, measure absorbance at the wavelength of 281nm by UV-Vis spectrophotometry (General rule 0401), precision weighing, plus hydrochloric acid solution (9-1000) dissolved and quantitatively diluted into each 1 ml containing minoxidil 4ug of the solution, the same method of determination, that is.

category storage

Same as minoxidil.

specification

2.5mg

Last Update：2022-01-01 11:54:18
Minoxidil
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QQ: 1332578202 Click to send a QQ messageSend QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Minoxidil Visit Supplier Webpage Request for quotation
CAS: 38304-91-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: minoxidil Request for quotation
CAS: 38304-91-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Minoxidil Visit Supplier Webpage Request for quotation
CAS: 38304-91-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Minoxidil Request for quotation
CAS: 38304-91-5
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
SHANDONG OCTAGON CHEMICALS LIMITED
Product Name: minoxidil Request for quotation
CAS: 38304-91-5
Tel: 15589503653
Email: sales@octagonchem.com
Mobile: 15589503653
QQ: 2283421579 Click to send a QQ messageSend QQ message
Hubei guoheng pharmaceutical technology co., ltd
Product Name: Minoxidil Request for quotation
CAS: 38304-91-5
Tel: 15572577573
Email: 1332578202@qq.com
Mobile: 16602705536
QQ: 1332578202 Click to send a QQ messageSend QQ message
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Minoxidil
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