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Moc-L-叔亮氨酸

(S)-N-(METHOXYCARBONYL)-TERT-LEUCINE

CAS: 162537-11-3

Molecular Formula: C8H15NO4

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Moc-L-叔亮氨酸 - Names and Identifiers

Name (S)-N-(METHOXYCARBONYL)-TERT-LEUCINE
Synonyms MOC-L-tert.Leucine
Moc-L-Tert-Leucine
MOC-L-tert. Leucin
Methylcarbonyl-L-t-leucine
Methylcarbonyl-L-tert-Leucine
Atazanavir related coMpound A
Methoxycarbonyl-L-tert-leucine
N-Methoxycarbonyl-tert-leucine
N-Methylcarbonyl-L-tert-Leucine
(S)-N-(METHOXYCARBONYL)-TERT-LEUCINE
N-(methoxycarbonyl)-3-methyl-L-valine
N-(Methoxycarbonyl)-3-methyl-L-valine
L-Valine,N-(Methoxycarbonyl)-3-Methyl-
(S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid
CAS 162537-11-3
EINECS 1308068-626-2
InChI InChI=1/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1
InChIKey NWPRXAIYBULIEI-RXMQYKEDSA-N

Moc-L-叔亮氨酸 - Physico-chemical Properties

Molecular FormulaC8H15NO4
Molar Mass189.21
Density1.126±0.06 g/cm3(Predicted)
Melting Point1090C
Boling Point320.9±25.0 °C(Predicted)
Flash Point147.9°C
Water Solubility26.4g/L at 20℃
Solubility Soluble in ethyl acetate and methanol.
Vapor Presure0Pa at 25℃
AppearanceWhite crystalline powder
pKa4.46±0.10(Predicted)
Storage Condition2-8°C
Refractive Index1.459
MDLMFCD07778455

Moc-L-叔亮氨酸 - Risk and Safety

HS Code2933399090

Moc-L-叔亮氨酸 - Reference Information

update date:2022/11/12 10:05:38
LogP0.832 at 21℃
application N-methoxycarbonyl-L-tert-leucine can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development and chemical production process.
preparation Na2CO3 (8.9g, 84
mmol) was added to 1N NaOH (168 mL) solution of L-alanine (8g, 168 mmol). The solution was cooled to 0°C and methyl chloroformate (20.5 mL, 172
mmol) was added dropwise. The reaction mixture was stirred at room temperature for 3.5 hours. The solution was washed with Et2O and acidified with 1N
HCl to a pH of about 1. The water layer was extracted with DCM, the organic layer was washed with brine, dried with Na2SO4, and concentrated to obtain the target intermediate N-methoxycarbonyl-L-tert-leucine.
Last Update:2024-04-09 15:16:48
Moc-L-叔亮氨酸
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