Monomethylhydrazine
Methylhydrazine
CAS: 60-34-4
Molecular Formula: CH6N2
Monomethylhydrazine - Names and Identifiers
Monomethylhydrazine - Physico-chemical Properties
| Molecular Formula | CH6N2 |
| Molar Mass | 46.07 |
| Density | 0.875g/mLat 20°C(lit.) |
| Melting Point | -21 °C |
| Boling Point | 88-90°C(lit.) |
| Flash Point | 70°F |
| Water Solubility | soluble |
| Solubility | Soluble in alcohol and ether (Weast, 1986) |
| Vapor Presure | 37.5 mm Hg ( 20 °C) |
| Vapor Density | 1.6 (vs air) |
| Appearance | liquid |
| Color | colorless to pale yellow |
| Exposure Limit | Potential occupational carcinogen. NIOSH REL: 2-h ceiling 0.04 ppm (0.08mg/m3), IDLH 20 ppm; OSHA PEL: ceiling 0.2 ppm (0.35 mg/m3); ACGIH TLV: TWA 0.01 ppm(adopted). |
| Merck | 13,6109 |
| BRN | 635645 |
| pKa | 8.84±0.70(Predicted) |
| Storage Condition | Flammables area |
| Stability | Stable. Flammable. Hygroscopic. Incompatible with strong oxidizing agents, copper, iron and their alloys. |
| Explosive Limit | 97% |
| Refractive Index | n20/D 1.4325(lit.) |
| Physical and Chemical Properties | |
| Use | For Organic synthesis |
Monomethylhydrazine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R24/25 - R26 - Very Toxic by inhalation R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R45 - May cause cancer R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S53 - Avoid exposure - obtain special instructions before use. S24/25 - Avoid contact with skin and eyes. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 1244 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | MV5600000 |
| HS Code | 29280000 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 orally in mice, rats: 33.0, 32.5 mg/kg (Witkin); orally in rats: 70.7 mg/kg (Gregory) |
Monomethylhydrazine - Upstream Downstream Industry
| Raw Materials | Chlorine Sodium hydroxide Ammonia Methylamine |
Monomethylhydrazine - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | methylhydrazine is an intermediate of the herbicide pyrisulfuron-methyl, the acaricide, and the acaricide, zacaride, and pyrimethamine. used in organic synthesis. N-methyl dimethyl hydrazide can be obtained by the acylation reaction of hydrazine sulfate. Formic acid, sodium formate and hydrazine sulfate were added into the glass-lined reaction pot, and the temperature was slowly raised to 110-115 ° C., followed by stirring for 1.5h. It was cooled to 5 ° C., filtered and washed with absolute ethanol. The filtrate was washed together, concentrated under reduced pressure and extracted with chloroform. The aggressive liquid was distilled off chloroform under reduced pressure, allowed to cool, and anhydrous ethanol and ether were added. A solid precipitated out, was filtered, washed with a small amount of diethyl ether, and was dried in direct air to obtain N-methyldimethylhydrazide. Melting point 50-51 °c. The yield ranged from 70% to 80%. For the production of the drug methylphenylhydrazine. Hydrazine is also used in rocket fuel. |
| production method | hydrazine hydrate, benzaldehyde as raw materials, by condensation, methylation reaction derived. 39% hydrazine hydrate was added to the reaction pot, and Benzaldehyde was added dropwise with stirring at 20-30 ° C. For about 7 hours, and stirring was continued for 2 hours, and the mixture was left overnight. The next day, it was filtered, washed with water until it was nearly neutral, and dried to obtain granular solid benzylidene nitrogen, melting point 90-93 ° C., yield over 95%. Benzene, benzylidene nitrogen and dimethyl sulfate were added into the reaction pot, and the mixture was refluxed for 5H under closed stirring. After cooling, solid was precipitated, water was added, the solid was dissolved, layered, and subjected to steam distillation until Benzaldehyde was not distilled out. Anhydrous ethanol was added to precipitate a solid, which was cooled and filtered to obtain methyl hydrazine sulfate. The yield was 60%-70%. The product is prepared by reacting methylamine with chloramine (NH2Cl). CH3NH2+NH2Cl→CH3NHNH2+HCl |
| category | toxic substances |
| toxicity grade | highly toxic |
| Acute toxicity | oral-rat LD50: 32 mg/kg; Oral-mouse LD50: 29 mg/kg |
| stimulation data | corrosive |
| explosive hazard characteristics | mixture of high temperature and air can be exploded |
| flammability hazard characteristics | flammable; Toxic nitrogen oxide gas emitted from fire scene |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from acids and oxidants. |
| fire extinguishing agent | water, sand, foam, carbon dioxide, dry powder in mist. |
| Occupational Standard | TWA 0.35 mg/m3 |
| spontaneous combustion temperature | 385 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 20 ppm |
Last Update：2024-04-10 22:29:15
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