Motilium
Domperidone
CAS: 57808-66-9
Molecular Formula: C22H24ClN5O2
Motilium - Names and Identifiers
| Name | Domperidone |
| Synonyms | kw-5338 Motilium Domperidone DoMperidone-d6 DOMPERIDONE BASE Domperidone,Motilium midazol-1-yl)propyl)-4-piperidinyl)- DoMperidone Sustained Release Pellets alpha-[2-(diisopropylamino) ethyl]-alpha-phenyl-2-pyridineacetamide 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one |
| CAS | 57808-66-9 |
| EINECS | 260-968-7 |
| InChI | InChI=1/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
| InChIKey | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
Motilium - Physico-chemical Properties
| Molecular Formula | C22H24ClN5O2 |
| Molar Mass | 425.91 |
| Density | 1.2904 (rough estimate) |
| Melting Point | 240-244°C |
| Water Solubility | Slightly soluble in water. |
| Solubility | DMSO 48 mg/mL Water <1 mg/mL Ethanol 1 mg/mL |
| Appearance | solid |
| Color | white |
| Merck | 14,3418 |
| pKa | pKa 7.90 (Uncertain) |
| Storage Condition | Store at RT |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5400 (estimate) |
| MDL | MFCD00069256 |
| Physical and Chemical Properties | White crystalline powder from dimethylformamide-water, melting point 242.5 °c |
| Use | Anticholinergic antispasmodic |
Motilium - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R62 - Possible risk of impaired fertility R63 - Possible risk of harm to the unborn child |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DE2275900 |
| HS Code | 29333990 |
Motilium - Reference
| Reference Show more | 1. Qiao Yujun, Jia Chen, Cao Aijia, Zhang Rui, Hua Xi, Jiao Haisheng. Effect of sodium valproate on pharmacokinetics of Tanshinone ⅱa in epileptic rats [J]. Modern Chinese medicine research and practice, 2020,34(06):31-35. 2. Mengqiu Lu, Haizhen Liang, Pengfei Tu, Yong Jiang. Pharmacodynamic comparison of two different source plants of Murrayae Folium et Cacumen[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(1): 49-57.doi: 10.5246/jcps.2021.1.0005 |
Motilium - Nature
Open Data Verified Data
white or off-white powder. Slightly soluble in ethanol, very slightly soluble in acetone. Practically insoluble in water. Generally stable. Melting point 242.5 °c.
Last Update：2024-01-02 23:10:35
Motilium - Preparation Method
Open Data Verified Data
2-nitro-1, 4-= chlorobenzene and 4-amino cyclohexyl carboxylic acid ethyl ester reaction, re-hydrogenation reduction, and urea cyclization, hydrolysis, 5 monochloro 1-(piperidin-4-yl) -1.3-dihydro -2H-benzoxazol-2-one was obtained. In addition, the nucleophilic substitution of hydroxypropylamine with 2-nitrochlorobenzene was performed, followed by hydrogenation and reduction, cyclization with potassium cyanide followed by chlorination to obtain 1-(3-chloropropyl)-2,3-= hydrogen -1H-benzobilazol -2 ketone. The above two compounds were stirred with sodium carbonate, potassium iodide and 4-methyl -2-pentanone, and domperidone was obtained.
Last Update：2022-01-01 09:23:20
Motilium - Standard
Authoritative Data Verified Data
This product is 5-chloro-l-[l-[3-(2, 3-dihydro-2-oxo-1h-benzimidazol-1-yl) propyl]-4-pyridinyl]-1, 3-dihydro-2h-benzimidazol-2-one. Calculated as dried product, the content of C22H24C1N502 shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
Motilium - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder, odorless.
- This product is very slightly soluble in methanol, almost insoluble in water; Soluble in glacial acetic acid.
Last Update：2022-01-01 11:53:42
Motilium - Introduction
Domperidone is a dopamine receptor inhibitor and an anti-dopamine agent.
Last Update：2022-10-16 17:26:33
Motilium - Use
Open Data Verified Data
developed by pharmaceutical company Janssen, Belgium. Dopamine receptor antagonist with strong effect, with peripheral blocking effect, directly acting on the gastrointestinal wall, can increase the tension of lower esophageal sphincter, prevent gastroesophageal reflux, enhance gastric peristalsis, promote gastric emptying, coordination of gastric and duodenal movement, inhibit Nausea, Vomit, and can effectively prevent bile reflux, does not affect the secretion of gastric juice. It is suitable for dyspepsia caused by delayed gastric emptying, gastroesophageal reflux, esophagitis, such as upper abdominal distension, upper abdominal pain, belching, flatulence, Nausea, Vomit, burning sensation of the stomach in the mouth with or without reflux of the contents of the stomach. Because it has almost no inhibitory effect on dopamine receptors in the brain, it has no mental and neurological side effects. And can be used for taking dopamine receptor agonist treatment of Parkinson's disease caused by Nausea.
Last Update：2022-01-01 09:23:21
Motilium - Differential diagnosis
Authoritative Data Verified Data
- take an appropriate amount of this product and make a solution containing 20ug per lml of isopropyl alcohol for determination by UV-Vis spectrophotometry (General rule 0401), there is a maximum absorption at a wavelength of 289nm and 232nm, and a minimum absorption at a wavelength of 257mn.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 606).
- about 20mg of this product is mixed with 0.10g of anhydrous sodium carbonate, and then it is allowed to cool. The residue is added with 10ml of water, heated and dissolved, filtered, and the filtrate is identified as chloride (1). Response (General rule 0301).
Last Update：2022-01-01 11:53:43
Motilium - Exam
Authoritative Data Verified Data
Related substances
weigh about 0.1kg of this product accurately, put it in a 10ml measuring flask, add N,N-dimethylformamide to dissolve and dilute to the scale, shake well, and use it as a test solution, A solution containing 25ug of domperidone per 1 ml was prepared as a control solution by dilution with N,N-dimethylformamide. Determined by high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane was used as filler; Methanol was used as mobile phase A, 0.5% ammonium acetate solution was used as mobile Phase B, and gradient elution was carried out according to the following table. The flow rate was 1.2ml per minute; The detection wavelength was 285nm. Take domperidone and Droperidol about 15mg each, put them in 100ml measuring flask, add N, N-dimethylformamide to dissolve and dilute to scale, shake well, take 10u1 and inject human liquid chromatograph, the degree of separation of domperidone from Droperidol and other adjacent impurity peaks should meet the requirements. 10 u1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.25% ), and the sum of each impurity peak area shall not be greater than 2 times the area of the main peak of the control solution (0.5%).
residual solvent
methanol, dichloromethane, Tetrahydrofuran, N, N-dimethylformate Amine, toluene and xylene take about 0.2g of this product, weigh it accurately, put it in a 20ml headspace bottle, and add 2ml of dimethyl sulfoxide precisely, ultrasonic dissolution, seal, as a test solution; Take methanol, dichloromethane, Tetrahydrofuran, N, N-dimethylformamide, toluene and xylene each appropriate amount, precision weighing, prepare a mixed solution containing about 150ug of methanol, 60ug of dichloromethane, 72ug of tetrahydrofuran, 176ug of N, N-dimethylformamide, 44.5ug of toluene and 217ug of xylene per 1 ml of dimethyl sulfoxide, and take 2ml of the solution with a precise amount, A 20ml headspace bottle was placed, sealed, and used as a control solution. Determined as residual solvent assay (General 0861). A capillary column with 100% dimethylpolysiloxane (or similar polar) as the stationary liquid is used as the chromatographic column; The starting temperature is 40°C, the temperature is maintained for 9 minutes, and the temperature is raised to 120°C at a rate of 8°C per minute for 2 minutes, then at a rate of 20°C per minute to 160°C; Injection port temperature of 200°C; Detector for flame ionization detector (FID ), detector temperature of 250°C; Column flow rate of 2.5 per minute, the split ratio was 1:1, the headspace bottle equilibration temperature was 100°C, and the equilibration time was 30 minutes. Take the reference solution into the headspace, and the separation degree between the peaks of each component shall meet the requirements. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. According to the external standard method to calculate the peak area, the residue should be in accordance with the provisions.
chloroform
take about 0.2g of this product, accurately weigh it, put it in a 5ml measuring flask, add dimethyl sulfoxide to dissolve and dilute to the scale, shake it well, and use it as a test solution, A solution containing about 2.4ug of chloroform per 1 ml was prepared using dimethyl sulfoxide as a control solution. Determined as residual solvent assay (General 0861). The capillary column with 6% cyanopropylphenyl-94% dimethylpolysiloxane (or similar polarity) as the stationary liquid was used as the chromatographic column; The initial temperature was 60 ° C. For 6 minutes, the temperature was raised to 200°C at a rate of 20°C per minute for 4 minutes; The inlet temperature was 200°C; The detector was an electron capture detector (ECD), and the detector temperature was 300°C; column flow rate of 4.5 per minute, split ratio of 15:1. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. According to the external standard method to calculate the peak area, the residue should comply with the provisions.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take this product l.Og, check according to law (General rule 0841), shall not pass 0.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:53:44
Motilium - Content determination
Authoritative Data Verified Data
take about 0.35g of this product, precision weighing, add 40ml of glacial acetic acid to dissolve, add 1 drop of crystal violet indicator solution, and use perchloric acid titration solution (0.1 mol/L) titration to the solution showed blue-green, and the titration results were corrected by blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 42.59mg of C22H24C1N502.
Last Update：2022-01-01 11:53:45
Motilium - Category
Authoritative Data Verified Data
gastrointestinal motility drugs.
Last Update：2022-01-01 11:53:45
Motilium - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:53:45
Motilium - Domperidone tablets
Authoritative Data Verified Data
This product contains domperidone (C22H24C1N502) should be labeled the amount of 90.0% ~ 110.0%.
trait
This product is white tablet.
identification
- Take appropriate amount of fine powder of this product (about 10mg equivalent to Domperidone), add dichloromethane-methanol (1:1) 10ml, shake to dissolve domperidone, filter, the filtrate was used as a test solution; An appropriate amount of domperidone reference product was additionally dissolved in dichloromethane-methanol (1:1) to prepare a solution containing 1 mg per 1 ml as a reference solution. According to the thin layer chromatography (General 0502) test, absorb 10ul of each of the above two solutions, and respectively point on the same silica gel GF 254 thin layer plate, with ethyl acetate-dichloromethane-methanol-acetate buffer (pH 4.7 )(10ml of lmol/L acetic acid solution and 30ml of water, mix well, adjust the pH value to 4.7 with lmol/L sodium hydroxide solution, dilute to 50ml with water)(54:23:18:5) as the developing solvent, spread out, dry, and put under UV light (254nm). The position and color of the main spot displayed by the test solution should be consistent with the position and color of the main spot of the reference solution.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- Related substances take an appropriate amount of fine powder of this product (about 25mg equivalent to Domperidone), put it in a 50ml measuring flask, and add about 25ml of the mobile phase under the content determination item to dissolve domperidone, then dilute to the scale with the above mobile phase, shake, filter, and take the filtrate as the test solution. Take 1ml of the test solution in a precise amount and put it in a 100ml measuring flask, as a control solution, it was diluted to the scale with the mobile phase as described above and shaken. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to twice the retention time of the main peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- Content uniformity: Take 1 tablet of this product, put it in mortar for fine grinding, add appropriate amount of methanol for grinding and move it into 25ml measuring flask (5mg specification) or 50ml measuring flask (lOmg specification), sonicate domperidone, cool, dilute to scale with methanol, shake,
- filter, Take 5ml of the filtrate with precision, put it in a 25ml measuring flask, dilute to the scale with the mobile phase under the content determination item, shake well, and measure it according to the method under the content determination item, the provisions shall be met (General rule 0941).
- dissolution dissolution of this product, according to the dissolution and release determination method (General 0931 second method), sodium chloride 2G, add appropriate amount of water to dissolve, add hydrochloric acid 7ml, then dilute to 1000ml with water, shake, take 500ml as dissolution medium, speed is 75 rpm, operate according to law, after 30 minutes, take appropriate amount of solution, filter, take the filtrate as the test solution; Take the appropriate amount of domperidone reference substance, make the solution containing 1 mg per 1ml with methanol, take 1ml with precision, and put the 100ml measuring flask (5mg specification) or in a 50ml measuring flask (lOmg specification), dilute to scale with dissolution medium, shake well, and use as a reference solution by UV-Vis spectrophotometry (General 0401), the absorbance was measured at a wavelength of 284mn, and the elution amount of each tablet was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0521).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; Methanol -0.5% ammonium acetate (60:40) as mobile phase; The detection wavelength was 285nm; the column temperature was 30°C. The number of theoretical plates is not less than 3000 based on the calculation of domperidone peak.
- determination of 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 10mg equivalent to Domperidone), put in a 50ml measuring flask, add an appropriate amount of methanol, ultrasonic dissolution of domperidone, cool, dilute to the scale with methanol, shake well, filter, Take 5ml of filtrate accurately, put it in a 25ml measuring flask, dilute to the scale with mobile phase, shake well, as a sample solution, 20u1 was accurately weighed and human liquid chromatograph was injected, and the chromatogram was recorded. Another domperidone reference substance was about 10mg, placed in a 50ml measuring flask, and the appropriate amount of methanol was added, dilute with methanol to the scale, shake, Take 5ml precision, put 25ml flask, dilute with mobile phase to the scale, shake, the same method. According to the external standard method to calculate the peak area, that is.
category
Same as domperidone.
specification
(l)5mg (2)10mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:53:46
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Product Name: Domperidone Visit Supplier Webpage Request for quotationCAS: 57808-66-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Domperidone Request for quotation
CAS: 57808-66-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 57808-66-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Product Name: Domperidone Visit Supplier Webpage Request for quotationCAS: 57808-66-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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