Myricetrin
3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-benzopyran-4-one
CAS: 17912-87-7
Molecular Formula: C21H20O12
Myricetrin - Names and Identifiers
Myricetrin - Physico-chemical Properties
| Molecular Formula | C21H20O12 |
| Molar Mass | 464.38 |
| Density | 1.88±0.1 g/cm3(Predicted) |
| Melting Point | 197°C(lit.) |
| Boling Point | 896.6±65.0 °C(Predicted) |
| Specific Rotation(α) | -138.6 (c, 0.5 in MeOH) |
| Flash Point | 315.6°C |
| JECFA Number | 2207 |
| Solubility | Soluble in DMSO, hot methanol, slightly soluble in water and absolute ethanol. |
| Vapor Presure | 1.44E-34mmHg at 25°C |
| Appearance | pale yellow flake crystal |
| Color | Light yellow to Yellow to Orange |
| pKa | 6.16±0.40(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.805 |
| MDL | MFCD00016930 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in water, soluble in methanol, ethanol, glacial acetic acid, from storage, Bayberry Bark, bayberry leaves. |
| In vitro study | Myricitrin, a compound isolated from the bark of the waxberry Myrica rubra, exerts analgesic effects. In rodent models of chemical and mechanical pain, Myricitrin produces significant analgesia by preventing activation of protein kinase C (PKC) α and PKC ε by phorbol ester (PMA). Another study demonstrated that the opening of voltage and small conductance calcium-gated K (+) channels and the reduction of calcium influx are responsible for the analgesic effect of myricitrin. Myricitrin also activates caspase-3 and MAPK signaling pathways by inhibiting p53 gene expression, and change the expression pattern of pro-apoptotic and anti-apoptotic genes and reduce the apoptosis induced by H 2 O 2 in vascular endothelial cells. |
| In vivo study | In mice, myricitrin (I. p. 10 mg/kg or 30 mg/kg) blocked apomorphine-induced stereotyped behavior and climbing and increased hindlimb withdrawal time (HRT). |
Myricetrin - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29389090 |
Myricetrin - Reference
| Reference Show more | 1. Guo Shuangshuang Zheng Fangfang Ke Cong Xue et al. Analysis of Enzymatic Properties of α-L-rhamnosidase from Pediococcus lactis AS1.2696 [J]. Food Science 2019 040(004):160-169. 2. [IF = 4.098] Chunlin Li et al."Rapid and non-destructive discrimination of special-grade flat green tea using Near-infrared spectroscopy." Spectrochim Acta A. 2019 Jan;206:254 3. [IF = 3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds." Microb Pathogenesis. 2019 Jan;126:56 4. [IF = 5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects." Fro 5. [IF = 4.879] Yang Liu et al."UV-B Radiation Largely Promoted transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings." Biomolecules. 2020 Apr;10(4):504 6. [IF = 4.411] Min Yang et al."Comparative Transcriptome Analysis of Ampelopsis megalophylla for Identifying Genes Involved in Flavonoid Biosynthesis and Accumulation during Different Seasons." Molecules. 2019 Jan;24(7):1267 7. [IF = 4.36] Zhao-Yi Wang et al."Integrated strategy of LC-MS and network pharmacology for predicting active constituents and pharmacological mechanisms of Ranunculus japonicus Thunb. for treating rheumatoid arthritis." J Ethnopharmacol. 2021 May;271:113818 8. [IF = 6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, kinetics and Interaction Mechanism." Frontiers in Nutrition. 2022; 9: 892426 |
Myricetrin - Nature
Open Data Verified Data
The melting point of myricetin containing one crystal of water of crystallization is 194 to 197 °c.
Last Update：2024-01-02 23:10:35
Myricetrin - Preparation Method
Open Data Verified Data
The fruits, bark and leaves of Myrica rubra were extracted with water, ethanol or methanol and refined.
Last Update：2022-01-01 11:13:50
Myricetrin - Use
Open Data Verified Data
can be used as an antioxidant. Added to cosmetics, has the effect of whitening the skin.
Last Update：2022-01-01 11:13:50
Myricetrin - Reference Information
| FEMA | 4491 | MYRICITRIN |
| Biological activity | Myricitrin (Myricitrine) is a chemical compound that can be isolated from the root bark of Myrica cerifera (Bayberry genus, small tree, native to North America). |
| Target | Value |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has the effects of constricting blood vessels, raising blood pressure, exciting the heart, choleretic, anti-inflammatory, mutagenic, etc. product name myricin; myricin; pentahydroxyflavone-3-rhamnoside |
Last Update：2024-04-09 21:32:04
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Product Name: Myricetrin Request for quotationCAS: 17912-87-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Myricetrin Visit Supplier Webpage Request for quotationCAS: 17912-87-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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