N-(tert-Butoxycarbonyl)-L-phenylalanine
N-Boc-L-phenyl alanine
CAS: 13734-34-4
Molecular Formula: C14H19NO4
N-(tert-Butoxycarbonyl)-L-phenylalanine - Names and Identifiers
N-(tert-Butoxycarbonyl)-L-phenylalanine - Physico-chemical Properties
| Molecular Formula | C14H19NO4 |
| Molar Mass | 265.3 |
| Density | 1.1356 (rough estimate) |
| Melting Point | 85-87°C(lit.) |
| Boling Point | 408.52°C (rough estimate) |
| Specific Rotation(α) | 24·5 ° (C=1, EtOH) |
| Flash Point | 211.8°C |
| Solubility | Soluble in methanol, dichloromethane, dimethylformamide and N-methyl-2-pyrrolidone. |
| Vapor Presure | 4.88E-08mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White |
| BRN | 2219729 |
| pKa | 3.88±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 24.5 ° (C=1, EtOH) |
| MDL | MFCD00002663 |
| Physical and Chemical Properties | White crystalline powder; Insoluble in petroleum ether, soluble in ethyl acetate, ethanol and DMF;mp is 84-86 ℃; Specific optical rotation [α]20D 22.5 °- 25.5 °(0.5-2.0 mg/ml ethanol) |
| Use | For the synthesis of proteins and peptides, widely used in medicine, biochemistry, food, cosmetics and other products synthesis |
N-(tert-Butoxycarbonyl)-L-phenylalanine - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29242990 |
N-(tert-Butoxycarbonyl)-L-phenylalanine - Reference
| Reference Show more | 1. [IF=3.373] Zhichen Cai et al."A comprehensive study of the aerial parts of Lonicera japonica Thunb. based on metabolite profiling coupled with PLS-DA."Phytochem Analysis. 2020 Nov;31(6):786-800 |
N-(tert-Butoxycarbonyl)-L-phenylalanine - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Used for polypeptide synthesis and as an amino acid protective monomer. It is used in the synthesis of proteins and peptides, and is widely used in the synthesis of various products such as medicine, biochemistry, food, cosmetics, etc. It is used in the synthesis of biochemical reagents and peptides. |
| Production method | Suspension of L-phenylalanine in dioxane solution, acylation reaction with tert-butoxycarbonyl azide to obtain a crude product, and then obtained by ether extraction, acetic acid acidification, and recrystallization. |
Last Update：2024-04-09 15:16:47
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