N-(tert-butoxycarbonyl)-D-phenylalanine
BOC-D-Phenylalanine
CAS: 18942-49-9
Molecular Formula: C14H19NO4
N-(tert-butoxycarbonyl)-D-phenylalanine - Names and Identifiers
| Name | BOC-D-Phenylalanine |
| Synonyms | BOC-D-PHE BOC-D-PHE-OH Boc-D-Phe-OH BOC-D-Phenylalanine BOC-D-PHENYLALANINE N-Boc-D-phenylalanine N-T-BOC-D-PHENYLALANINE N-(TERT-BUTOXYCARBONYL)-D-PHENYLALANINE N-(tert-Butoxycarbonyl)-D-phenylalanine N-ALPHA-TERT-BUTYLOXYCARBONYL-D-PHENYLALANINE (2R)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate (R)-2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID |
| CAS | 18942-49-9 |
| EINECS | 606-177-6 |
| InChI | InChI=1/C14H19NO4/c1-14(2,3)19-13(18)15-11(12(16)17)9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/p-1/t11-/m1/s1 |
| InChIKey | ZYJPUMXJBDHSIF-LLVKDONJSA-N |
N-(tert-butoxycarbonyl)-D-phenylalanine - Physico-chemical Properties
| Molecular Formula | C14H19NO4 |
| Molar Mass | 265.3 |
| Density | 1.1356 (rough estimate) |
| Melting Point | 78-87°C |
| Boling Point | 408.52°C (rough estimate) |
| Specific Rotation(α) | -26 º (c=2,ethanol) |
| Flash Point | 211.8°C |
| Water Solubility | insoluble |
| Solubility | DMSO, Ethanol, Methanol |
| Vapor Presure | 4.88E-08mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| BRN | 3593396 |
| pKa | 3.88±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | -25 ° (C=1, EtOH) |
| MDL | MFCD00063149 |
| Physical and Chemical Properties | White crystalline powder; Insoluble in water and petroleum ether, soluble in ethyl acetate, ethanol and DMF;mp is 84-86 ℃; Specific optical rotation [α]20D-22.5 ° -25.5 °(0.5-2.0 mg/ml, ethanol). |
N-(tert-butoxycarbonyl)-D-phenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
N-(tert-butoxycarbonyl)-D-phenylalanine - Reference Information
| Use | Used for polypeptide synthesis and as an amino acid protective monomer. |
| Production method | Suspension of L-phenylalanine in dioxane solution, acylation reaction with tert-butoxycarbonyl azide to obtain a crude product, and then obtained by ether extraction, hydrochloric acid acidification, and recrystallization. |
Last Update：2024-04-09 21:21:28
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