N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide
CAS: 1171919-92-8
Molecular Formula: C11H15BrN2O2
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide - Names and Identifiers
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide - Physico-chemical Properties
| Molecular Formula | C11H15BrN2O2 |
| Molar Mass | 287.15 |
| Density | 1.470±0.06 g/cm3(Predicted) |
| Boling Point | 462.4±45.0 °C(Predicted) |
| pKa | 13.09±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Irritant |
| MDL | MFCD12401643 |
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide - Risk and Safety
| Hazard Class | IRRITANT |
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide - Introduction
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide, chemical formula is C12H15BrN2O2, belonging to organic compounds. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White crystal or crystalline powder.
-Solubility: Soluble in some organic solvents such as dichloromethane, ethyl acetate and dimethylformamide, insoluble in water.
-Molecular weight: 310.16g/mol.
Use:
- N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide is an important organic synthesis intermediate, widely used in the field of medicine and pesticide synthesis.
Preparation Method:
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide can be synthesized by the following steps:
1.2-bromo-5-(hydroxymethyl) pyridine-3-methanol and o-propylaluminum chloride are reacted in an organic solvent to obtain a precursor of N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide.
2. The precursor obtained in step 1 is reacted with pivalamide under appropriate reaction conditions to produce the final product N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide.
Safety Information:
-Wear appropriate protective equipment, including laboratory gloves, safety glasses and protective clothing, when using or handling the compound.
-Avoid direct contact with the skin, which can cause allergic reactions or irritation.
-Avoid inhaling dust, which may cause respiratory discomfort if inhaled in large quantities.
-It should be used in a well-ventilated environment to avoid inhalation of steam with high concentration.
-Store away from ignition and oxidizing agents.
Nature:
-Appearance: White crystal or crystalline powder.
-Solubility: Soluble in some organic solvents such as dichloromethane, ethyl acetate and dimethylformamide, insoluble in water.
-Molecular weight: 310.16g/mol.
Use:
- N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide is an important organic synthesis intermediate, widely used in the field of medicine and pesticide synthesis.
Preparation Method:
N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide can be synthesized by the following steps:
1.2-bromo-5-(hydroxymethyl) pyridine-3-methanol and o-propylaluminum chloride are reacted in an organic solvent to obtain a precursor of N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide.
2. The precursor obtained in step 1 is reacted with pivalamide under appropriate reaction conditions to produce the final product N-(2-Bromo-5-(hydroxymethyl)pyridin-3-yl)-pivalamide.
Safety Information:
-Wear appropriate protective equipment, including laboratory gloves, safety glasses and protective clothing, when using or handling the compound.
-Avoid direct contact with the skin, which can cause allergic reactions or irritation.
-Avoid inhaling dust, which may cause respiratory discomfort if inhaled in large quantities.
-It should be used in a well-ventilated environment to avoid inhalation of steam with high concentration.
-Store away from ignition and oxidizing agents.
Last Update：2024-04-09 02:00:57
